Amylmetacresol
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| Clinical data | |
|---|---|
| AHFS/Drugs.com | International Drug Names |
| Routes of administration | Oral |
| ATC code | R02AA20 (WHO) |
| Legal status | |
| Legal status | |
| Identifiers | |
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| CAS Number | 53043-14-4 |
| PubChem (CID) | 14759 |
| ChemSpider |
14076  |
| ChEMBL | CHEMBL1512677 |
| Chemical and physical data | |
| Formula | C12H18O |
| Molar mass | 178.27 |
| 3D model (Jmol) | Interactive image |
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| (verify) | |
Amylmetacresol (AMC) is an antiseptic used to treat infections of the mouth and throat. It is used as an active pharmaceutical ingredient in Strepsils, Cēpacol, Gorpils and Lorsept throat lozenges.
Chemically, AMC is derivative of m-cresol, with a pentyl group attached to the sixth carbon atom. The pure substance melts at 24 °C, and boils between 137 to 139 °C (at 6.7 kPa). It is soluble in water, ethanol, acetone, ether, and oil. AMC exhibits low toxicity, and a RW coefficient of 250.[1]
See also
References
- ↑ Twort, CC; Baker, AH (1942). "Further Researches on Bactericidal Mists and Smokes". The Journal of Hygiene. 42 (3): 266–283. doi:10.1017/s0022172400035476. PMC 2199819
. PMID 20475630.
External links
- C. E. Coulthard (1931). "The Disinfectant and Antiseptic Properties of Amyl-meta-cresol". J Exp Patho. 12 (5): 331–336. PMC 2048245.
- Oxford JS, Lambkin R, Gibb I, Balasingam S, Chan C, Catchpole A (2005). "A throat lozenge containing amyl meta cresol and dichlorobenzyl alcohol has a direct virucidal effect on respiratory syncytial virus, influenza A and SARS-CoV". Antivir Chem Chemother. 16 (2): 129–34. PMID 15889535.
- McNally D, Shephard A, Field E (2012). "Randomised, double-blind, placebo-controlled study of a single dose of an amylmetacresol/2,4-dichlorobenzyl alcohol plus lidocaine lozenge or a hexylresorcinol lozenge for the treatment of acute sore throat due to upper respiratory tract infection". J Pharm Pharm Sci. 15 (2): 281–94. PMID 22579007.
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