Synonyms 6-Chloro-17α-hydroxy-19-norpregna-4,6-dione
CAS Number 30781-27-2
PubChem (CID) 10315768
ChemSpider 8491233
UNII 6MB06022N0
Chemical and physical data
Formula C20H25ClO3
Molar mass 348.8637 g/mol
3D model (Jmol) Interactive image

Amadinone (INN), also known as 19-norchlormadinone, is a steroidal progestin of the 19-norprogesterone and 17α-hydroxyprogesterone groups that was synthesized and characterized in 1968 but was never marketed.[1][2] It has antigonadotropic properties, and for this reason, is a functional antiandrogen.[3][4] An acetate ester, amadinone acetate, also exists, but similarly was never marketed.[1]

See also


  1. 1 2 J. Elks (14 November 2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. pp. 35–. ISBN 978-1-4757-2085-3.
  2. William Andrew Publishing (22 October 2013). Pharmaceutical Manufacturing Encyclopedia, 3rd Edition. Elsevier. pp. 206–. ISBN 978-0-8155-1856-3.
  3. A. Hughes; S. H. Hasan; G. W. Oertel; H. E. Voss; F. Bahner; F. Neumann; H. Steinbeck; K.-J. Gräf; J. Brotherton; H. J. Horn; R. K. Wagner (27 November 2013). Androgens II and Antiandrogens / Androgene II und Antiandrogene. Springer Science & Business Media. pp. 495–. ISBN 978-3-642-80859-3.
  4. Kent, J. R.; Hill, M.; Huix, F. J.; Segre, E. J. (1972). "Seminal acid phosphatase content in the clinical bioassay of androgens and antiandrogens". Clinical Pharmacology & Therapeutics. 13 (2): 205–211. doi:10.1002/cpt1972132205. ISSN 0009-9236.

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