This article is about a non-clinically used progestin compound. For the pharmaceutical drug, see medroxyprogesterone acetate.
Clinical data
  • X
ATC code None
CAS Number 520-85-4
PubChem (CID) 1063110631
ChemSpider 10185
Chemical and physical data
Formula C22H32O3
Molar mass 344.488 g/mol
3D model (Jmol) Interactive image

Medroxyprogesterone (INN, BAN), also known as 17α-hydroxy-6α-methylprogesterone, and abbreviated as MP, is a steroidal progestin drug which was never marketed for use in humans.[1] An acylated derivative, medroxyprogesterone acetate (MPA), is clinically used as a pharmaceutical medicine.[2] Compared to MPA, MP is over two orders of magnitude less potent as a progestogen.[3] As such, MP itself is not used clinically, though it has seen limited use in veterinary medicine under the trade name Controlestril in France.[4] In addition, it is a metabolite of MPA.[5]

While medroxyprogesterone is sometimes used as a synonym for medroxyprogesterone acetate,[2] what is normally being administered is MPA and not MP.[6]

See also


  1. F.. Macdonald (1997). Dictionary of Pharmacological Agents. CRC Press. p. 1079. ISBN 978-0-412-46630-4. Retrieved 28 May 2012.
  2. 1 2 "MedroxyPROGESTERone: Drug Information Provided by Lexi-Comp". Merck Manual. 2009-12-01. Retrieved 2010-07-08.
  3. Pullen MA, Laping N, Edwards R, Bray J (September 2006). "Determination of conformational changes in the progesterone receptor using ELISA-like assays". Steroids. 71 (9): 792–8. doi:10.1016/j.steroids.2006.05.009. PMID 16784762.
  4. Index Nominum 2000: International Drug Directory. Taylor & Francis US. 2000. p. 638. ISBN 978-3-88763-075-1. Retrieved 28 May 2012.
  5. Ishihara M, Kirdani Y, Osawa Y, Sandberg AA (January 1976). "The metabolic fate of medroxyprogesterone acetate in the baboon". J. Steroid Biochem. 7 (1): 65–70. doi:10.1016/0022-4731(76)90167-9. PMID 1271819.
  6. Lenco W, Mcknight M, Macdonald AS (January 1975). "Effects of cortisone acetate, methylprednisolone and medroxyprogesterone on wound contracture and epithelization in rabbits". Ann. Surg. 181 (1): 67–73. doi:10.1097/00000658-197501000-00015. PMC 1343717Freely accessible. PMID 1119869.
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