Top: levonorgestrel, bottom: dextronorgestrel
Clinical data
AHFS/ Micromedex Detailed Consumer Information
MedlinePlus a602008
ATC code G03AA06 (WHO) G03FA10 (WHO) G03FB01 (WHO) (only combinations with estrogens)
Legal status
Legal status
Pharmacokinetic data
Biological half-life 5–14 hours
CAS Number 6533-00-2 YesY
PubChem (CID) 16051930
ChemSpider 10481953 YesY
UNII 3J8Q1747Z2 YesY
KEGG D00954 YesY
Chemical and physical data
Formula C21H28O2
Molar mass 312.446 g/mol
3D model (Jmol) Interactive image
 NYesY (what is this?)  (verify)

Norgestrel (INN, USAN, BAN, JAN) (brand names Logynon, Nordette, Eugynon, Microgynon, Ovran, Ovranette, Trinordiol, numerous others) is a steroidal progestin that has been used in hormonal contraceptives. It is a mixture of two stereoisomers, dextronorgestrel (CAS# 797-64-8 ) and levonorgestrel (CAS# 797-63-7 ).[1] Only levonorgestrel is biologically active.[2] Therefore, while some medications may contain dextronorgestrel, they are often labeled in terms of their levonorgestrel content only, ignoring the inert isomer.

Norgestrel has also been used as an emergency contraceptive in the Yuzpe regimen.[3]

See also


  1. Mutschler, Ernst; Schäfer-Korting, Monika (2001). Arzneimittelwirkungen (in German) (8 ed.). Stuttgart: Wissenschaftliche Verlagsgesellschaft. pp. 442f. ISBN 3-8047-1763-2.
  2. Benagiano, G; Carrara, S; Filippi, V (2009). "Safety, efficacy and patient satisfaction with continuous daily administration of levonorgestrel/ethinylestradiol oral contraceptives". Patient preference and adherence. 3: 131–43. PMC 2778424Freely accessible. PMID 19936155.
  3. Yuzpe, A. A.; Smith, R. P.; Rademaker, A. W. (1982). "A multicenter clinical investigation employing ethinyl estradiol combined with dl-norgestrel as postcoital contraceptive agent". Fertility and Sterility. 37 (4): 508–13. PMID 7040117.

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