Algestone acetophenide

Algestone acetophenide
Clinical data
Routes of
ATC code None
Synonyms 16α,17α-Dihydroxyprogesterone acetophenide
CAS Number 24356-94-3
PubChem (CID) 5284538
ChemSpider 4447595
Chemical and physical data
Formula C29H36O4
Molar mass 448.59 g/mol
3D model (Jmol) Interactive image

Algestone acetophenide (USAN) (brand names Neolutin, Droxone, Deladroxone, Decadroxone, Dexadroxate, Bovitrol), also known as dihydroxyprogesterone acetophenide (DHPA), is a steroidal progestin of the 17α-hydroxyprogesterone group that is used as a contraceptive.[1][2] It is marketed in combination with estradiol enanthate as a combined injectable contraceptive.[3][4][5] The drug is the ketal formed between algestone and acetophenone.[1][2] It is also described as a corticosteroid, similarly to other 17α-hydroxyprogesterone derivatives.[1] Algestone acetophenide is said to be both more potent and longer-acting than hydroxyprogesterone caproate.[6]

See also


  1. 1 2 3 J. Elks (14 November 2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. pp. 27–. ISBN 978-1-4757-2085-3.
  2. 1 2 William Andrew Publishing (22 October 2013). Pharmaceutical Manufacturing Encyclopedia, 3rd Edition. Elsevier. pp. 153–. ISBN 978-0-8155-1856-3.
  3. Newton JR, D'arcangues C, Hall PE (1994). "A review of "once-a-month" combined injectable contraceptives". J Obstet Gynaecol (Lahore). 4 Suppl 1: S1–34. doi:10.3109/01443619409027641. PMID 12290848.
  5. Rowlands, S (2009). "New technologies in contraception". BJOG: An International Journal of Obstetrics & Gynaecology. 116 (2): 230–239. doi:10.1111/j.1471-0528.2008.01985.x. ISSN 1470-0328.
  6. Kawakami M, Sawyer CH (1967). "Effects of sex hormones and antifertility steroids in brain thresholds in the rabbit". Endocrinology. 80 (5): 857–71. doi:10.1210/endo-80-5-857. PMID 4164655.
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