|Subcutaneous implant, vaginal ring, transdermal patch|
|Biological half-life||1–2 hours (oral)|
|Chemical and physical data|
|Molar mass||370.482 g/mol|
|3D model (Jmol)||Interactive image|
Segesterone acetate (USAN) (brand name Nestorone; former developmental code names ST-1435, AC-6844, CS-0411), known more commonly simply as nestorone (or nestoron), and also known as elcometrine, is a steroidal progestin of the 19-norprogesterone group which is used as a hormonal contraceptive in several South American countries. Segesterone acetate is the acetate ester of segesterone, which was never marketed, but is an active metabolite of segesterone acetate. Segesterone acetate is only weakly active orally, and is instead given as a subcutaneous implant. It is more than 100-fold times as potent when delivered subcutaneously relative to orally.
Segesterone acetate acts primarily as a high-affinity agonist of the progesterone receptor. It does not bind significantly tot he androgen receptor, estrogen receptor, or mineralocorticoid receptor. Segesterone acetate does however have some affinity for the glucocorticoid receptor, where it appears to act as an agonist, but it does not appear to produce any glucocorticoid side effects unless used at high doses. Segesterone acetate does not bind to sex hormone-binding globulin, and is instead bound to serum albumin.
Segesterone acetate is not available in the United States.
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