Clomegestone acetate
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| Identifiers | |
|---|---|
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| CAS Number | 424-89-5 |
| PubChem (CID) | 20055456 |
| ChemSpider | 16736896 |
| UNII | 8OIJ6341W7 |
| KEGG | D03550 |
| ChEMBL | CHEMBL2104126 |
| Chemical and physical data | |
| Formula | C24H31ClO4 |
| Molar mass | 418.95354 g/mol |
| 3D model (Jmol) | Interactive image |
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Clomegestone acetate (USAN) (developmental code name SH-741), or clomagestone acetate, also known as 6-chloro-17α-acetoxy-16α-methylpregna-4,6-diene-3,20-dione, is a steroidal progestin of the 17α-hydroxyprogesterone group that was developed as an oral contraceptive but was never marketed.[1][2] It is the acetate ester of clomegestone, which, similarly to clomegestone acetate, was never marketed.[1] Clomegestone acetate is also the 17-desoxy cogener of clometherone, and is somewhat more potent in comparison.[3] Similarly to cyproterone acetate, clomegestone acetate has been found to alter insulin receptor concentrations in adipose tissue, and this may indicate the presence of glucocorticoid activity.[4][5]
References
- 1 2 J. Elks (14 November 2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. pp. 297–. ISBN 978-1-4757-2085-3.
- ↑ Mary Margaret Lawrence (1971). CENTO Workshop Series on Clinical and Applied Research in Family Planning, Ankara, Turkey, February 23-26: Tehran, Iran, March 1-4; Lahore, Pakistan, March 9-12, 1971; [papers. Central Treaty Organization.
- ↑ Daniel Lednicer (20 June 2011). Steroid Chemistry at a Glance. John Wiley & Sons. pp. 5–. ISBN 978-1-119-95729-4.
- ↑ Krauth, M. C.; Schillinger, E. (1977). "CHANGES IN INSULIN RECEPTOR CONCENTRATION IN RAT FAT CELLS FOLLOWING TREATMENT WITH THE GESTAGENS CLOMEGESTONE ACETATE AND CYPROTERONE ACETATE". European Journal of Endocrinology. 86 (3): 667–672. doi:10.1530/acta.0.0860667. ISSN 0804-4643.
- ↑ Schillinger, E.; Gerloff, Ch.; Gerhards, E.; Gunzel, P. (1974). "GLUCOSE TOLERANCE AND SERUM INSULIN IN RATS AND INSULIN SENSITIVITY OF RAT ADIPOSE CELLS FOLLOWING TREATMENT WITH THE PROGESTOGEN CLOMEGESTONE ACETATE". European Journal of Endocrinology. 75 (2): 305–313. doi:10.1530/acta.0.0750305. ISSN 0804-4643.
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