Clinical data
Routes of
ATC code None
Legal status
Legal status
  • ℞ (Prescription only)
Synonyms Ro 4-8347; 1,6-bisdehydro-6-chlororetroprogesterone[1]
CAS Number 5192-84-7
PubChem (CID) 56840930
ChemSpider 16736068
Chemical and physical data
Formula C21H25ClO2
Molar mass 344.875 g/mol
3D model (Jmol) Interactive image

Trengestone (INN) (brand names Reteroid, Retroid, Retrone; former developmental code name Ro 4-8347), also known as 6-chloro-6,7-didehydroretroprogesterone or 6-chloro-9β-10α-pregna-1,4,6-triene-3,20-dione, is a steroidal progestin of the retroprogesterone group[2] related to dydrogesterone that was formerly used to treat menstrual disorders.[3][4][5] It was synthesized in 1964 and was introduced for medical use by Roche in 1974.[3][4][5]


  1. Andreoli C, Fiorentino F, Lenzi G (September 1970). "[Clinical studies and endometrial histomorphological findings by means of a new retroprogesterone derivative: 1,6 bis dehydro-6-chloro-retroprogesterone (Trengestone)]". Minerva Ginecol (in Italian). 22 (18): 874–9. PMID 4925556.
  2. J. Horsky; J. Presl (6 December 2012). Ovarian Function and its Disorders: Diagnosis and Therapy. Springer Science & Business Media. pp. 329–. ISBN 978-94-009-8195-9.
  3. 1 2 J. Elks (14 November 2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. pp. 259–. ISBN 978-1-4757-2085-3.
  4. 1 2 Pascale Brudon (1983). Médicaments pour tous en l'an 2000?: les multinationales pharmaceutiques suisses face au tiers monde : l'exemple du Mexique. Editions d'en bas. pp. 93–. ISBN 978-2-8290-0039-3.
  5. 1 2 Dr. Ian Morton; I.K. Morton; Judith M. Hall (31 October 1999). Concise Dictionary of Pharmacological Agents: Properties and Synonyms. Springer Science & Business Media. pp. 279–. ISBN 978-0-7514-0499-9.

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