Clinical data
ATC code None
Synonyms 9β,10α-Progesterone, 9β,10α-pregn-4-ene-3,20-dione
CAS Number 2755-10-4
PubChem (CID) 92940
ChemSpider 83898
Chemical and physical data
Formula C21H30O2
Molar mass 314.4617 g/mol
3D model (Jmol) Interactive image

Retroprogesterone, also known as 9β,10α-progesterone or as 9β,10α-pregn-4-ene-3,20-dione, is a synthetic steroid and stereoisomer of the natural progestogen, progesterone.[1][2] It is the parent compound of a group of progestins consisting of dydrogesterone (6-dehydroretroprogesterone) and trengestone (1,6-bis-dehydro-6-chloro-retroprogesterone).[1][2][3] Retroprogesterone itself binds with high affinity to the progesterone receptor as well.[4]

Ro 6-3129 (6-16-ethylthioretroprogesterone) is a retroprogesterone derivative that was never marketed.[5]

See also


  1. 1 2 J. Horsky; J. Presl (6 December 2012). Ovarian Function and its Disorders: Diagnosis and Therapy. Springer Science & Business Media. pp. 305, 329. ISBN 978-94-009-8195-9.
  2. 1 2 Lt Col Pankaj Talwar; Surveen Ghumann Sindhu (18 May 2012). Step by Step: Protocols in Clinical Embryology and ART. JP Medical Ltd. pp. 379–. ISBN 978-93-5025-765-4.
  3. Padubidri (1 January 2005). Gynaecology. Elsevier India. pp. 207–. ISBN 978-81-8147-562-6.
  4. Gerald Litwack (2 December 2012). Biochemical Actions of Hormones. Elsevier. pp. 193–. ISBN 978-0-323-15189-4.
  5. Dixon, Ross; Hudson, Sean; Darragh, Austin (1973). "Pharmacokinetics of the retro-steroid progestogen, 16α-ethylthio-9β,10α-pregna-4, 6-diene-3, 20-dione (Ro 6-3129), in man and the sheep". Contraception. 8 (1): 53–65. doi:10.1016/0010-7824(73)90159-5. ISSN 0010-7824.

This article is issued from Wikipedia - version of the 11/6/2016. The text is available under the Creative Commons Attribution/Share Alike but additional terms may apply for the media files.