Grape seed extract
Grape seed extract is an industrial derivative of whole grape seeds.
The extract contains proanthocyanidins. In alternative medicine, grape seed extract is sold in dietary supplement form and claimed to have numerous health benefits which are not supported by sufficient medical evidence.
Research and potential health effects
GSE is being investigated for its potential antibacterial properties.
A meta-analysis of randomized controlled trials concluded that "grape seed extract appears to significantly lower systolic blood pressure and heart rate, with no effect on lipid or C-reactive protein levels."
The US National Center for Complementary and Integrative Health reported that oral administration of grape seed extract was well tolerated in people over 8 weeks, although there are no studies yet indicating its effectiveness in treating diseases.
Side effects may include itchy scalp; dizziness, headache, high blood pressure or nausea.
- "Grape Seed Extract, Herbs at a Glance". US National Center for Complementary and Integrative Health, National Institutes of Health.
- Al-Habib A, Al-Saleh, E (2010). "Bactericidal effect of grape seed extract on methicillin-resistant Staphylococcus aureus (MRSA)". Journal of Toxicology Science. 357 (3): 357–64. PMID 20519844.
- Feringa, Harm H.H.; Laskey, Dayne A.; Dickson, Justine E.; Coleman, Craig I. (2011). "The Effect of Grape Seed Extract on Cardiovascular Risk Markers: A Meta-Analysis of Randomized Controlled Trials". Journal of the American Dietetic Association. 111 (8): 1173–81. doi:10.1016/j.jada.2011.05.015. PMID 21802563.