JWH-120

JWH-120

Identifiers
IUPAC name (4-methyl-1-naphthalenyl)(1-propyl-1H-indol-3-yl)methanone
CAS Number	824955-98-8 Y
PubChem (CID)	11461586
ChemSpider	9636426
ChEMBL	CHEMBL497811
Chemical and physical data
Formula	C23H21NO
Molar mass	327.42 g/mol
3D model (Jmol)	Interactive image
SMILES CCCN1C=C(C2=CC=CC=C21)C(=O)C3=CC=C(C4=CC=CC=C43)C
InChI InChI=1S/C23H21NO/c1-3-14-24-15-21(19-10-6-7-11-22(19)24)23(25)20-13-12-16(2)17-8-4-5-9-18(17)20/h4-13,15H,3,14H2,1-2H3 Key:DUBUGSKBMMXSOU-UHFFFAOYSA-N

JWH-120 is a synthetic cannabimimetic that was discovered by John W. Huffman. It is the N-propyl analog of JWH-122. It is a potent and selective ligand for the CB₂ receptor, with a binding affinity of K_i = 6.1 ± 0.7 nM at this subtype, and 173 times selectivity over the CB₁ subtype.^[1]

See also

• JWH-122
• JWH-193
• JWH-210
• JWH-398

References

1. ↑ Huffman, J.; et al. (2005). "Structure-activity relationships for 1-alkyl-3-(1-naphthoyl)indoles at the cannabinoid CB(1) and CB(2) receptors: steric and electronic effects of naphthoyl substituents. New highly selective CB(2) receptor agonists.". Bioorganic & Medicinal Chemistry. 13 (1): 89–112. doi:10.1016/j.bmc.2004.09.050. PMID 15582455.