Clinical data
Routes of
Synonyms KP201
CAS Number 1259440-61-3
ChemSpider 31484780
Chemical and physical data
Formula C25H25NO4
Molar mass 403.470
3D model (Jmol) Interactive image

Benzhydrocodone (INN) (contracted from benzoate-hydrocodone) is a opioid prodrug of the morphinan class. Its chemical structure consists of hydrocodone coupled with benzoic acid. Benzhydrocodone itself is inactive and acts as a prodrug to hydrocodone upon cleavage of the benzoate portion of the molecule.[1]

It is designed to be an opioid analgesic with a low chance of recreational use.[2]

Created by a biopharmaceutical company in Coralville, Iowa. President and CEO, Travis Mickle, believes the molecular-based approach to abuse-detterent may be more effective than many formulation-based approaches.[3]


  1. KemPharm, Inc. (June 11, 2013). "KemPharm, Inc. Receives Patent from the USPTO for Novel Pain Drug Candidate, KP201" (Press release). North Liberty, Iowa: PR Newswire. Retrieved February 8, 2015.
  2. Lavitt, John (June 12, 2014). "New Abuse-Resistant Opioid Receives $60 Million Backing". The Fix. Retrieved February 8, 2015. External link in |website= (help)
  3. "KP201/APAP". Retrieved April 20, 2015. External link in |website= (help)

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