PubChem (CID) 11049533
Chemical and physical data
Formula C27H31NO4
Molar mass 433.538 g/mol
3D model (Jmol) Interactive image

N-Phenethyl-14-ethoxymetopon is a drug that is a derivative of metopon. It is a potent analgesic, around 60 times stronger than morphine and produces significantly less constipation.[1]

N-Phenethyl-14-ethoxymetopon acts as an agonist at both μ- and δ-opioid receptors, with a Ki of 0.16nM at μ and 3.14nM at δ.[2]

See also


  1. Ananthan, S (2006). "Opioid ligands with mixed μ/δ opioid receptor interactions: An emerging approach to novel analgesics". The AAPS Journal. 8 (1): E118–25. doi:10.1208/aapsj080114. PMC 2751430Freely accessible. PMID 16584118.
  2. Lattanzi, R; Spetea, M; Schüllner, F; Rief, SB; Krassnig, R; Negri, L; Schmidhammer, H (2005). "Synthesis and biological evaluation of 14-alkoxymorphinans. 22.(1) Influence of the 14-alkoxy group and the substitution in position 5 in 14-alkoxymorphinan-6-ones on in vitro and in vivo activities". Journal of Medicinal Chemistry. 48 (9): 3372–8. doi:10.1021/jm040894o. PMID 15857143.

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