Clinical data
AHFS/Drugs.com International Drug Names
Routes of
ATC code none
Legal status
Legal status
CAS Number 15687-14-6 YesY
PubChem (CID) 27453
DrugBank DB01487 YesY
ChemSpider 25547 YesY
KEGG D03984 YesY
ECHA InfoCard 100.036.149
Chemical and physical data
Formula C17H27NO3
Molar mass 293.401 g/mol
3D model (Jmol) Interactive image

Embutramide (INN, USAN, BAN) (brand name Embutane) is a potent opioid analgesic and sedative drug that is structurally related to methadone.[1][2][3] It was developed by Hoechst A.G. in 1958[4] and was investigated as a general anesthetic agent, but was found to have a very narrow therapeutic window, with a 50 mg/kg dose producing effective sedation and a 75 mg/kg dose being fatal. Along with strong sedative effects, embutramide also produces respiratory depression and ventricular arrhythmia. Because of these properties, it was never been adopted for medical use as an anesthetic as it was considered too dangerous for this purpose. Instead it is used for euthanasia in veterinary medicine, mainly for the euthanization of dogs.

Embutramide is formulated as a combination product under the brand name Tributame, which also contains chloroquine and lidocaine.[5]

Embutramide is used for euthanasia of a range of different animals, mainly small animals kept as pets rather than large farm animals. It may cause significant pain to the animal being euthanized,[6] and so may be less humane than older drugs used for this purpose such as pentobarbital, however it may have less abuse potential than barbiturates especially in the Tributame combination formulation, and so is less likely to be diverted for recreational abuse.[7] Embutramide has however been reported to be used for suicide by people with access to the drug,[8][9] and was added to the list of Schedule III drugs in the USA in 2006, as a Non-Narcotic with ACSCN 2020, which classifies it with depressants such as benzodiazepines, barbitutates, and other sedative-hypnotics..[10]


  1. J. Elks (14 November 2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. pp. 482–. ISBN 978-1-4757-2085-3.
  2. Dr. Ian Morton; I.K. Morton; Judith M. Hall (31 October 1999). Concise Dictionary of Pharmacological Agents: Properties and Synonyms. Springer Science & Business Media. pp. 108–. ISBN 978-0-7514-0499-9.
  3. Michael E. Peterson; Patricia A. Talcott (7 August 2013). Small Animal Toxicology. Elsevier Health Sciences. pp. 315–. ISBN 978-0-323-24198-4.
  4. US Patent 3045043
  5. Hellebrekers LJ, Baumans V, Bertens AP, Hartman W. The use of T61 for the humane killing of pets and laboratory animals. Tijdschrift voor Diergeneeskdunde. (Dutch) 1990 Jul 1;115(13):625-32.
  6. DEA lists embutramide as schedule III controlled substance
  7. Smith RA, Lewis D. Suicide by ingestion of T-61. Veterinary and Human Toxicology. 1989 Aug;31(4):319-20.
  8. Kintz P, Cirimele V, Ludes B. Blood investigation in a fatality involving the veterinary drug T-61. Journal of Analytical Toxicology. 2002 Oct;26(7):529-31.
  9. DEA lists embutramide as schedule III controlled substance. Journal of the American Veterinary Medical Association. 2006 Nov 1;229(9):1358.

This article is issued from Wikipedia - version of the 10/1/2016. The text is available under the Creative Commons Attribution/Share Alike but additional terms may apply for the media files.