Clinical data
ATC code none
Synonyms Cocculine
CAS Number 115-53-7 YesY
PubChem (CID) 5459308
ChemSpider 10179905 N
ECHA InfoCard 100.003.722
Chemical and physical data
Formula C19H23NO4
Molar mass 329.390 g/mol
3D model (Jmol) Interactive image
 NYesY (what is this?)  (verify)

Sinomenine or cocculine is an alkaloid found in the root of the climbing plant Sinomenium acutum which is native to Japan and China. It is traditionally used in herbal medicine in these countries, as a treatment for rheumatism and arthritis.[1] However, its analgesic action against other kinds of pain is limited. Sinomenine is a morphinan derivative, related to opioids such as levorphanol and the non-opioid cough suppressant dextromethorphan. Its anti-rheumatic effects are thought to be primarily mediated via release of histamine,[2] but other effects such as inhibition of prostaglandin, leukotriene and nitric oxide synthesis may also be involved.[3]

See also


  1. Zhao, ZZ; Liang, ZT; Zhou, H; Jiang, ZH; Liu, ZQ; Wong, YF; Xu, HX; Liu, L (2005). "Quantification of sinomenine in caulis sinomenii collected from different growing regions and wholesale herbal markets by a modified HPLC method". Biological & Pharmaceutical Bulletin. 28 (1): 105–9. doi:10.1248/bpb.28.105. PMID 15635172.
  2. Yamasaki, H (1976). "Pharmacology of sinomenine, an anti-rheumatic alkaloid from Sinomenium acutum". Acta medica Okayama. 30 (1): 1–20. PMID 61710.
  3. Liu, L; Riese, J; Resch, K; Kaever, V (1994). "Impairment of macrophage eicosanoid and nitric oxide production by an alkaloid from Sinomenium acutum". Arzneimittel-Forschung. 44 (11): 1223–6. PMID 7848335.
This article is issued from Wikipedia - version of the 9/8/2016. The text is available under the Creative Commons Attribution/Share Alike but additional terms may apply for the media files.