ITGAV

ITGAV
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1JV2, 1L5G, 1M1X, 1U8C, 3IJE, 4G1E, 4G1M, 4MMX, 4MMY, 4MMZ, 4O02, 4UM8, 4UM9
Identifiers
Aliases	ITGAV, CD51, MSK8, VNRA, VTNR, integrin subunit alpha V
External IDs	MGI: 96608 HomoloGene: 20510 GeneCards: ITGAV
Gene ontology Molecular function • transforming growth factor beta binding • metal ion binding • voltage-gated calcium channel activity • virus receptor activity • protein kinase C binding • protease binding • extracellular matrix protein binding • extracellular matrix binding • fibronectin binding • opsonin binding • insulin-like growth factor I binding • protein binding • fibroblast growth factor binding • neuregulin binding • coreceptor activity • C-X3-C chemokine binding Cellular component • lamellipodium membrane • integrin alphav-beta3 complex • extracellular exosome • alphav-beta3 integrin-IGF-1-IGF1R complex • integral component of membrane • integrin alphav-beta5 complex • membrane • focal adhesion • intracellular • integrin alphav-beta8 complex • ruffle membrane • integrin complex • microvillus membrane • filopodium membrane • external side of plasma membrane • phagocytic vesicle • plasma membrane • integral component of plasma membrane • cell surface Biological process • regulation of phagocytosis • angiogenesis • apoptotic cell clearance • endodermal cell differentiation • apolipoprotein A-I-mediated signaling pathway • negative chemotaxis • negative regulation of lipid storage • negative regulation of low-density lipoprotein particle receptor biosynthetic process • extracellular matrix organization • heterotypic cell-cell adhesion • positive regulation of cell migration • regulation of apoptotic cell clearance • substrate adhesion-dependent cell spreading • vascular endothelial growth factor receptor signaling pathway • cell-matrix adhesion • viral process • antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent • viral entry into host cell • blood vessel development • negative regulation of entry of bacterium into host cell • integrin-mediated signaling pathway • positive regulation of cell proliferation • calcium ion transmembrane transport • negative regulation of macrophage derived foam cell differentiation • negative regulation of extrinsic apoptotic signaling pathway • leukocyte migration • cell-substrate adhesion • entry of symbiont into host cell by promotion of host phagocytosis • negative regulation of lipoprotein metabolic process • negative regulation of lipid transport • cell migration • extrinsic apoptotic signaling pathway in absence of ligand • positive regulation of cell adhesion • ERK1 and ERK2 cascade • cell growth • positive regulation of osteoblast proliferation • cell adhesion • cell adhesion mediated by integrin Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	3685	16410
Ensembl	ENSG00000138448	ENSMUSG00000027087
UniProt	P06756	P43406
RefSeq (mRNA)	NM_001144999 NM_001145000 NM_002210	NM_008402
RefSeq (protein)	NP_001138471.1 NP_001138472.1 NP_002201.1	NP_032428.2
Location (UCSC)	Chr 2: 186.59 – 186.68 Mb	Chr 2: 83.72 – 83.81 Mb
PubMed search	[1]	[2]
Wikidata

Integrin alpha-V is a protein that in humans is encoded by the ITGAV gene.^[3]

ITAGV encodes integrin alpha chain V. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. Alpha V undergoes post-translational cleavage to yield disulfide-linked heavy and light chains, that combine with multiple integrin beta chains to form different integrins. Among the known associating beta chains (beta chains 1,3,5,6, and 8; 'ITGB1', 'ITGB3', 'ITGB5', 'ITGB6', and 'ITGB8'), each can interact with extracellular matrix ligands; the alpha V beta 3 integrin, perhaps the most studied of these, is referred to as the Vitronectin receptor (VNR). In addition to adhesion, many integrins are known to facilitate signal transduction.^[4]

Alpha V class integrins

In mammals the integrins that include alpha-V are :

As a drug target

The mAbs intetumumab, and abituzumab target this protein which is found on some tumour cells.^[6]

See also

• Cluster of differentiation

References

Further reading

PDB gallery
1jv2: CRYSTAL STRUCTURE OF THE EXTRACELLULAR SEGMENT OF INTEGRIN ALPHAVBETA3  1l5g: CRYSTAL STRUCTURE OF THE EXTRACELLULAR SEGMENT OF INTEGRIN AVB3 IN COMPLEX WITH AN ARG-GLY-ASP LIGAND  1m1x: CRYSTAL STRUCTURE OF THE EXTRACELLULAR SEGMENT OF INTEGRIN ALPHA VBETA3 BOUND TO MN2+  1u8c: A novel adaptation of the integrin PSI domain revealed from its crystal structure

External links

• CD51 Antigen at the US National Library of Medicine Medical Subject Headings (MeSH)
• ITGAV Info with links in the Cell Migration Gateway