Michael Stuart Brown

For other people named Michael Brown, see Michael Brown (disambiguation).
Michael Brown
Born Michael Stuart Brown
(1941-04-13) April 13, 1941
Brooklyn, New York, USA
Nationality United States
Fields Biology
Alma mater
Known for Regulation of cholesterol metabolism
Notable awards
Spouse Alice Lapin (m. 1964)
Children two

Michael Stuart Brown (born April 13, 1941) is an American geneticist and Nobel laureate. He was awarded the Nobel Prize in Physiology or Medicine with Joseph L. Goldstein in 1985 for describing the regulation of cholesterol metabolism.[2][3][4][5]

Education and early life

Brown was born in Brooklyn, New York, the son of Evelyn, a homemaker, and Harvey Brown, a textile salesman.[4][6] Graduated from Cheltenham High School (Wyncote, PA). Brown graduated from the University of Pennsylvania in 1962 and received his M.D. from the University of Pennsylvania School of Medicine in 1966.

Career and research

Moving to the University of Texas Health Science Center in Dallas, now the UT Southwestern Medical Center, Brown and colleague Joseph L. Goldstein researched cholesterol metabolism and discovered that human cells have low-density lipoprotein (LDL) receptors that extract cholesterol from the bloodstream. The lack of sufficient LDL receptors is implicated in familial hypercholesterolemia, which predisposes heavily for cholesterol-related diseases. In addition to explaining the underlying pathology of this disease, their work uncovered a fundamental aspect of cell biology - Receptor-mediated endocytosis.

Their findings led to the development of statin drugs, the cholesterol-lowering compounds that today are used by 16 million Americans and are the most widely prescribed medications in the United States. Their discoveries are improving more lives every year, both in the United States and around the world[needs citation]. New federal cholesterol guidelines will triple the number of Americans taking statin drugs to lower their cholesterol, reducing the risk of heart disease and stroke for countless people. Following these important advances, their team of dedicated researchers elucidated the role of lipid modification of proteins (protein prenylation) in cancer. In 1984 he was awarded the Louisa Gross Horwitz Prize from Columbia University together with Joseph L. Goldstein (Co-recipient of 1985 Nobel Prize in Physiology or Medicine). In 1988, Brown received National Medal of Science for his contributions to the world of Medicine.

In 1993, their trainees Xiaodong Wang and Michael Briggs purified the Sterol regulatory element binding proteins (SREBPs). Since 1993, Drs. Brown, Goldstein, and their colleagues have described the unexpectedly complex machinery by which cells maintain the necessary levels of fats and cholesterol in the face of varying environmental circumstances. Dr. Brown holds The W. A. (Monty) Moncrief Distinguished Chair in Cholesterol and Arteriosclerosis Research; is a Regental Professor of the University of Texas; holds the Paul J. Thomas Chair in Medicine; and is a member of the Board of Scientific Directors at The Scripps Research Institute. Frequently mentioned as a candidate for nationally-prominent positions in scientific administration, Dr. Brown, like his colleague Joseph L. Goldstein, elects to continue hands-on involvement with research, leading a research team that typically includes a dozen doctoral and postdoctoral trainees. He and his colleague are among the most highly cited scientists in the world.

Brown is also on the prestigious Prix Galien USA Committee that "recognizes the technical, scientific and clinical research skills necessary to develop innovative medicines". The inauguration of the Prix Galien in the US, the equivalent of the Nobel Prize in this field, was in September 2007, and the winners were selected by a preeminent scientific and learned committee that included 7 Nobel laureates, of which Brown was one.

Awards and honors

Brown has won numerous awards and honors including:



  1. 1 2 "Professor Michael Brown ForMemRS". London: Royal Society. Archived from the original on 2015-11-06.
  2. "Biography: Michael S. Brown". The Notable Names Database. Soylent Communications. 2008. Retrieved 2008-06-15.
  3. "Michael Brown - Nobel Prize Inspiration Initiative". Nobelprizeii.org. Retrieved 2015-11-06.
  4. 1 2 "Michael S. Brown - Biographical". Nobelprize.org. 1941-04-13. Retrieved 2015-11-06.
  5. "Michael S. Brown - Nobel Lecture: A Receptor-Mediated Pathway for Cholesterol Homeostasis". Nobelprize.org. 1985-12-08. Retrieved 2015-11-06.
  6. "BROWN (Brown), Michael, photo, biography". Persona.rin.ru. 1941-04-13. Retrieved 2015-11-06.
  7. "Earl and Thressa Stadtman Distinguished Scientist Award". Asbmb.org. Retrieved 2015-11-06.
  8. "University of Texas Southwestern Medical Center Leaders to Receive Research!America Advocacy Award". Research!America. 2007-03-21. Retrieved 2015-11-06.
  9. Archived October 8, 2013, at the Wayback Machine.
  10. "Herbert Tabor Research Award". Asbmb.org. Retrieved 2015-11-06.
  11. "Albany Medical College: 2003". Amc.edu. 2015-08-14. Retrieved 2015-11-06.
  12. Daniel W. Foster; Jean D. Wilson. "Presentation of the Kober Medal to Joseph L. Goldstein and Michael S. Brown" (PDF). Jci.org. Retrieved 2015-11-06.
  13. Archived April 10, 2012, at the Wayback Machine.
  14. "The President's National Medal of Science: Recipient Details | NSF - National Science Foundation". Nsf.gov. Retrieved 2015-11-06.
  15. "1985 Basic Medical Research Award". The Lasker Foundation. 2007-09-16. Retrieved 2015-11-06.
  16. "Past ASHG Award Recipients". ASHG. Retrieved 2015-11-06.
  17. "Joseph L. Goldstein". Gairdner. Retrieved 2015-11-06.
  18. http://www.nasonline.org/member-directory/members/57317.html
  19. "Richard Lounsbery Award". Nasonline.org. Retrieved 2015-11-06.
  20. Archived October 7, 2012, at the Wayback Machine.
  21. "Pfizer Award in Enzyme Chemistry". Divbiolchem.org. Retrieved 2015-11-06.
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