Thomas Earl Starzl|
March 11, 1926
Le Mars, Iowa, U.S.
|Residence||Pittsburgh, Pennsylvania, U.S.|
|Institutions||University of Pittsburgh|
BA, Westminster College, 1947|
MD, Northwestern University, 1952
PhD, Northwestern University, 1952
Performed the first human liver transplant in 1963|
Developed the clinical applications of cyclosporin
Contributed to the field of immunosuppression
Thomas Earl Starzl (born March 11, 1926) is an American physician, researcher, and is an expert on organ transplants. He performed the first human liver transplants, and has often been referred to as "the father of modern transplantation."
Starzl was born on March 11, 1926, in Le Mars, Iowa, the son of newspaper editor and science fiction writer Roman Frederick Starzl and Anna Laura Fitzgerald who was a teacher and a nurse. He is the second of four siblings. Originally intending to become a priest in his teenage years, Starzl's plans changed drastically when his mother died from breast cancer in 1947.
He attended Westminster College in Fulton, Missouri, where he earned a Bachelor of Science degree in biology. Starzl attended Northwestern University Medical School in Chicago, where in 1950 he received a Master of Science degree in anatomy and in 1952 earned both a Ph.D. in neurophysiology and an M.D. with distinction. While attending medical school, he established a long friendship with Professor Loyal Davis, MD a neurosurgeon.
Starzl spent an extra year at medical school, using the additional time to complete a doctorate in neurophysiology, in 1952. He wrote a seminal paper describing a technique to record the electrical responses of deep brain structures to sensory stimuli such as a flash of light or a loud sound. The paper is still cited today.
After obtaining his medical degree, Starzl trained in surgery at Johns Hopkins Hospital in Baltimore and Jackson Memorial Hospital in Miami. At both places, he conducted lab and animal research, showing a keen interest in liver biology.
Starzl was a surgeon and researcher in the then nascent field of organ transplantation at the University of Colorado from 1962 until his move to the University of Pittsburgh in 1981, where he has remained since. He made an exceptional mark on the medical community creating new surgical techniques. He reportedly worked up to three days straight on organ transplantation procedures as he was the only one who could perform them.
The Institute for Scientific Information released information in 1999 that documented that his work had been cited more than any other researcher in the world. Between 1981 and June 1998, he was cited 26,456 times.
His autobiographical memoir, The Puzzle People, was named by The Wall Street Journal as the third best book on doctors' lives.
Starzl's most notable accomplishments include:
- Performing the first human liver transplant in 1963, and the first successful human liver transplant in 1967, both at the University of Colorado Health Sciences Center.
- Establishing the clinical utility of ciclosporin (cyclosporine) in 1982, and tacrolimus in 1991, both leading to FDA approval;
- Development of multiple technical advances in organ preservation, procurement and transplant;
- Delineating the indications and limitations of abdominal organ transplantation;
- Defining the underlying basis for organ transplantation as a treatment of inherited metabolic diseases (thus providing the rationale for current-day gene therapy efforts);
- Recognizing the causative role of immunosuppression in the development of post-transplant lymphoproliferative disease and other opportunistic infections and the utility of reversing the immunosuppressed state as the principal treatment;
- Performing the first simultaneous heart and liver transplant on six-year-old Stormie Jones in 1984;
- Proposing microchimerism in organ transplant tolerance.
Awards and honors
- Benjamin Franklin Medal for Distinguished Achievement in the Sciences (2016, American Philosophical Society)
- Anthony Cerami Award in Translational Medicine (2015, editors of Molecular Medicine)
- Baruch S. Blumberg Prize (2014, Hepatitis B Foundation)
- Lasker Award (2012, Lasker Foundation) for clinical medical research
- Carnegie Science Chairman's Award (2010, Carnegie Science Center)
- Gustav O. Lienhard Award (2009, National Institute of Medicine)
- Physician of the Year Award for Lifetime Achievement (2009) presented by Castle Connolly Medical.
- National Medal of Science (2004), presented by President George W. Bush at the White House in 2006
- John Scott Award (2004)
- King Faisal International Prize for Medicine (2001)
- Lannelongue International Medal (1998, Académie Nationale de Chirurgie)
- Jacobson Innovation Award (1995, American College of Surgeons)
- Peter Medawar Prize (1992, The Transplantation Society)
- William Beaumont Prize in Gastroenterology (1991, American Gastroenterological Association)
- Distinguished Service Award (1991, American Liver Foundation)
- Golden Plate Award, (1983 Academy of Achievement)
- David M. Hume Memorial Award (1978, National Kidney Foundation)
- Brookdale Award in Medicine (1974, American Medical Association)
- Bigelow Medal (Boston Surgical Society)
- City of Medicine Award
Starzl was named one of the most important people of the Millennium, ranking No. 213, according to the authors of "1,000 Years, 1,000 People: Ranking the Men and Women Who Shaped the Millennium " (Kodansha America, 332 pp.)
Starzl has also received honorary degrees from 26 universities in the United States and abroad, which include 12 in Science, 11 in Medicine, 2 in Humane Letters, and 1 in Law.
In 2006, at a celebration for his 80th birthday, the University of Pittsburgh renamed one of its newest medical research buildings the Thomas E. Starzl Biomedical Science Tower in recognition of his achievements and contributions to the field. On October 15, 2007, the Western Pennsylvania American Liver Foundation and the City of Pittsburgh honored Starzl by dedicating Lothrop Street, near his office and the biomedical research tower bearing his name, as "Thomas E. Starzl Way".
Retired from clinical and surgical service since 1991, Dr. Starzl now devotes his time to research endeavors and remains active as professor of surgery at the University of Pittsburgh School of Medicine and the University of Pittsburgh Medical Center’s (UPMC) program named in his honor: the Thomas E. Starzl Transplantation Institute. Since his “retirement,” he has earned the additional distinctions of being one of the most prolific scientists in the world as well as the most cited scientist in the field of clinical medicine.
- Cronin, Mike (2010-01-29). "Starzl, Tribune-Review reporters claim Carnegie Science Awards". Pittsburgh Tribune-Review. Retrieved 2010-01-29.
- Pioneer without peer: In May 1999, the Institute for Scientific Information announced that Starzl's work had been cited more than that of any other researcher in the world -- 26,456 times between 1981 and June 1998, or about 4,000 more times than the next-ranked researcher., publisher=Pittsburgh Post Gazette |first=Anita| last=Srikameswaran| date= June 11, 2000| accessdate: September 11, 2015
- Starzl, Thomas (1992). The Puzzle People: Memoirs of a Transplant Surgeon. Pittsburgh: University of Pittsburgh Press. ISBN 0-8229-3714-X.
- Verghese, Abraham (2010-07-10). "Five Best". The Wall Street Journal. Retrieved 2010-07-31.
- Milestones in Organ Transplantation National Kidney Foundation
- Starzl TE, Klintmalm GB, Porter KA, Iwatsuki S, Schröter GP (1981). "Liver transplantation with use of cyclosporin a and prednisone". N. Engl. J. Med. 305 (5): 266–9. doi:10.1056/NEJM198107303050507. PMC 2772056. PMID 7017414.
- New York Times. February 20, 1990. New Liver for Stormie Jones. Retrieved on July 2, 2007.
- Roth, Mark (2012-09-10). "Pioneering Pitt transplant surgeon Starzl receives Lasker Award". Pittsburgh Post-Gazette. Retrieved 2015-09-11.
- Roth, Mark (2009-10-12). "Starzl receives national award". Pittsburgh Post-Gazette. Pittsburgh, PA. Retrieved 2009-10-12.
- Associated Press, Transplant pioneer Starzl to receive award, 2009-03-18, Pittsburgh Post-Gazette, accessdate=2009-03-18
- Reston, Maeve (February 14, 2006). "President gives Starl highest prize". Pittsburgh Post-Gazette. Retrieved 7 August 2011.
- Anderson, Maria W. (2004-11-25). "2004 John Scott Awards - Thomas Starzl and Barry Trost recognized in awards that aim to reward contributions to mankind". The Scientist. Philadelphia, PA. Retrieved 2009-11-16.
- "Thomas Starzl Interview with Academy of Achievement". Retrieved 2014-06-02.
- "David M. Hume Memorial Award". National Kidney Foundation Web site. National Kidney Foundation. Retrieved 7 August 2011.
- Srikameswaran, Anita (March 11, 2006). "Pitt names tower after transplant pioneer". Pittsburgh Post-Gazette. Retrieved 7 August 2011.
- Enconomides, Nadia; Lothrop Street dedicated to Dr. Starzl; The Pitt News; 2007-10-16; accessdate=2008-08-21
- University of Pittsburgh Medical Center