STK4

STK4
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3COM, 4NR2, 4OH8, 2JO8
Identifiers
Aliases	STK4, KRS2, MST1, TIIAC, YSK3, serine/threonine kinase 4
External IDs	MGI: 1929004 HomoloGene: 55965 GeneCards: STK4
Targeted by Drug
bosutinib[1]
Gene ontology Molecular function • transferase activity • protein kinase activity • nucleotide binding • protein dimerization activity • protein homodimerization activity • transcription factor binding • protein serine/threonine kinase activator activity • metal ion binding • kinase activity • protein serine/threonine kinase activity • protein binding • identical protein binding • ATP binding • magnesium ion binding • signal transducer, downstream of receptor, with serine/threonine kinase activity Cellular component • cytoplasm • cytosol • protein complex • nucleus Biological process • regulation of cell differentiation involved in embryonic placenta development • positive regulation of extrinsic apoptotic signaling pathway via death domain receptors • positive regulation of protein phosphorylation • intracellular signal transduction • phosphorylation • protein stabilization • hippo signaling • keratinocyte differentiation • positive regulation of peptidyl-serine phosphorylation • endocardium development • protein phosphorylation • primitive hemopoiesis • central nervous system development • peptidyl-serine phosphorylation • cell morphogenesis • positive regulation of apoptotic process • branching involved in blood vessel morphogenesis • protein autophosphorylation • positive regulation of protein binding • cell differentiation involved in embryonic placenta development • positive regulation of fat cell differentiation • negative regulation of organ growth • neural tube formation • negative regulation of canonical Wnt signaling pathway • signal transduction • negative regulation of cell proliferation • hepatocyte apoptotic process • apoptotic process • signal transduction by protein phosphorylation • positive regulation of protein serine/threonine kinase activity Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	6789	58231
Ensembl	ENSG00000101109	ENSMUSG00000018209
UniProt	Q13043	Q9JI11
RefSeq (mRNA)	NM_006282	NM_021420
RefSeq (protein)	NP_006273.1	NP_067395.1
Location (UCSC)	Chr 20: 44.97 – 45.08 Mb	Chr 2: 164.07 – 164.16 Mb
PubMed search	[2]	[3]
Wikidata

Serine/threonine-protein kinase 4 is an enzyme that in humans is encoded by the STK4 gene.^[4][5][6]

Function

The protein encoded by this gene is a cytoplasmic kinase that is structurally similar to the yeast Ste20p kinase, which acts upstream of the stress-induced mitogen-activated protein kinase cascade. The encoded protein can phosphorylate myelin basic protein and undergoes autophosphorylation. A caspase-cleaved fragment of the encoded protein has been shown to be capable of phosphorylating histone H2B. The particular phosphorylation catalyzed by this protein has been correlated with apoptosis, and it's possible that this protein induces the chromatin condensation observed in this process.^[7]

Interactions

STK4 has been shown to interact with PRKRIR.^[8]

STK4 has also been shown to prevent, through Yap1 coactivator modulation, haematological tumor cell apoptosis. Cottini F, Hideshima T, Xu C, Sattler M, Dori M, Agnelli L, ten Hacken E, Bertilaccio MT, Antonini E, Neri A, Ponzoni M, Marcatti M, Richardson PG, Carrasco R, Kimmelman AC, Wong KK, Caligaris-Cappio F, Blandino G, Kuehl WM, Anderson KC, Tonon G (2014). "Rescue of Hippo coactivator YAP1 triggers DNA damage-induced apoptosis in hematological cancers". Nat. Med. 20 (6): 599–606. doi:10.1038/nm.3562. PMID 24813251. 

References

Further reading

PDB gallery
2jo8: Solution structure of C-terminal domain of human mammalian sterile 20-like kinase 1 (MST1)