Nepafenac

Nepafenac
Clinical data

Trade names	Nevanac
AHFS/Drugs.com	Monograph
MedlinePlus	a606007
Pregnancy category	US: C (Risk not ruled out)
Routes of administration	Ophthalmic
ATC code	S01BC10 (WHO)
Legal status
Legal status	US: ℞-only
Identifiers
IUPAC name 2-amino-3-benzoylbenzeneacetamide
PubChem (CID)	151075
IUPHAR/BPS	7564
DrugBank	DB06802^Y
ChemSpider	133160^Y
UNII	0J9L7J6V8C^Y
KEGG	D05143^Y
ChEBI	CHEBI:75922^N
ChEMBL	CHEMBL1021^Y
ECHA InfoCard	100.207.414
Chemical and physical data
Formula	C₁₅H₁₄N₂O₂
Molar mass	254.28 g/mol
3D model (Jmol)	Interactive image
SMILES O=C(c1cccc(c1N)CC(=O)N)c2ccccc2
InChI InChI=1S/C15H14N2O2/c16-13(18)9-11-7-4-8-12(14(11)17)15(19)10-5-2-1-3-6-10/h1-8H,9,17H2,(H2,16,18)^Y Key:QEFAQIPZVLVERP-UHFFFAOYSA-N^Y
^NY (what is this?) (verify)

Nepafenac is a non-steroidal anti-inflammatory drug (NSAID), usually sold as a prescription eye drop 0.1% solution. Nepafenac is manufactured by Alcon and sold under the trade name Nevanac. It is used to treat pain and inflammation associated with cataract surgery.^[1]

The usual dose is one drop, thrice a day, in each affected eye beginning one day prior to cataract surgery, continued on the day of surgery and through the first two weeks of the postoperative period.^[1]

Nepafenac is a prodrug of amfenac, an inhibitor of COX-1 and COX-2 activity.^[2]^[3] Its side effects may include decreased visual acuity, a feeling that something is in the eye, increased eye pressure or a sticky sensation, as well as other effects.^[1]

Brand names of Nepafenac include Ilevro and Nevanac.

References

1 2 3 Nepafenac Monograph
↑ Drugbank: Nepafenac
↑ Lira, R. P.; Fulco, E. A.; Chaves, A.; Da Costa Pinto, F.; Arieta, F. R.; Lira, C. E. (2012). "Effect of preoperative use of topical prednisolone acetate, ketorolac tromethamine, nepafenac and placebo, on the maintenance of intraoperative mydriasis during cataract surgery: A randomized trial". Indian Journal of Ophthalmology. 60 (4): 277–281. doi:10.4103/0301-4738.98705. PMC 3442462. PMID 22824596.

Non-steroidal anti-inflammatory drugs (NSAIDs) (primarily M01A and M02A, also N02BA)

Pyrazolones / Pyrazolidines	Aminophenazone Ampyrone Azapropazone Clofezone Difenamizole Famprofazone Feprazone Kebuzone Metamizole Mofebutazone Morazone Nifenazone Oxyphenbutazone Phenazone Phenylbutazone Propyphenazone Sulfinpyrazone Suxibuzone^‡

Salicylates	Aspirin (acetylsalicylic acid)^# Aloxiprin Benorylate Carbasalate calcium Diflunisal Dipyrocetyl Ethenzamide Guacetisal Magnesium salicylate Methyl salicylate Salsalate Salicin Salicylamide Salicylic acid (salicylate) Sodium salicylate

Acetic acid derivatives and related substances	Aceclofenac Acemetacin Alclofenac Amfenac Bendazac Bromfenac Bumadizone Bufexamac Diclofenac Difenpiramide Etodolac Felbinac Fenclozic acid Fentiazac Indomethacin Indomethacin farnesil Isoxepac Ketorolac Lonazolac Oxametacin Prodolic acid Proglumetacin Sulindac Tiopinac Tolmetin Zomepirac^†

Oxicams	Ampiroxicam Droxicam Isoxicam Lornoxicam Meloxicam Piroxicam Tenoxicam

Propionic acid derivatives (profens)	Alminoprofen Benoxaprofen^† Carprofen^‡ Dexibuprofen Dexketoprofen Fenbufen Fenoprofen Flunoxaprofen Flurbiprofen Ibuprofen^# Ibuproxam Indoprofen^† Ketoprofen Loxoprofen Miroprofen Naproxen Oxaprozin Pirprofen Suprofen Tarenflurbil Tepoxalin^‡ Tiaprofenic acid Vedaprofen^‡ COX-inhibiting nitric oxide donator: Naproxcinod

N-Arylanthranilic acids (fenamates)	Azapropazone Clonixin Etofenamate Flufenamic acid Flunixin Meclofenamic acid Mefenamic acid Morniflumate Niflumic acid Tolfenamic acid Flutiazin

Coxibs	Apricoxib Celecoxib Cimicoxib^‡ Deracoxib^‡ Etoricoxib Firocoxib^‡ Lumiracoxib^† Mavacoxib^‡ Parecoxib Robenacoxib^‡ Rofecoxib^† Valdecoxib^†

Other	Aminopropionitrile Benzydamine Chondroitin sulfate Diacerein Fluproquazone Glucosamine Glycosaminoglycan Hyperforin Nabumetone Nimesulide Oxaceprol Proquazone Superoxide dismutase/Orgotein Tenidap

Items listed in bold indicate initially developed compounds of specific groups. ^#WHO-EM ^†Withdrawn drugs. ^‡Veterinary use medications.

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