Transient neonatal diabetes mellitus

Transient neonatal diabetes mellitus
Classification and external resources
Specialty pediatrics
ICD-10 P70.2
OMIM 601410 610374 610582

Transient neonatal diabetes mellitus (TNDM) is a form of diabetes mellitus presenting at birth that is not permanent. This disease is considered to be a type of maturity onset diabetes of the young (MODY).

Types include:

Type OMIM Gene Locus Description
TNDM1 601410 ZFP57, PLAGL1 6p22.1, 6p24.2
TNDM2 610374 ABCC8 11p15.1 Due to the mutations of the other subunit of the KATP channel, SUR1, which is encoded by the ABCC8 gene.[1]
TNDM3 610582 KCNJ11 11p15.1

It is to do with genetics and is often associated with having an added Chromosome 7 gene (mostly from the paternal side).

The form on chromosome 6 can involve imprinting.[2]



  1. de Wet H, Proks P, Lafond M, et al. (May 2008). "A mutation (R826W) in nucleotide-binding domain 1 of ABCC8 reduces ATPase activity and causes transient neonatal diabetes". EMBO Rep. 9 (7): 648–54. doi:10.1038/embor.2008.71. PMC 2475326Freely accessible. PMID 18497752.
  2. Raphaël Scharfmann (2007). Development of the Pancreas and Neonatal Diabetes. Karger Publishers. pp. 113–. ISBN 978-3-8055-8385-5. Retrieved 10 November 2010.
  3. "Other Forms (MODY, LADA, Neonatal)". Retrieved 20 November 2014.

See also

This article is issued from Wikipedia - version of the 7/2/2016. The text is available under the Creative Commons Attribution/Share Alike but additional terms may apply for the media files.