FGF13

FGF13
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3HBW, 4DCK, 4JPZ
Identifiers
Aliases	FGF13, FGF-13, FGF2, FHF-2, FHF2, fibroblast growth factor 13
External IDs	MGI: 109178 HomoloGene: 3036 GeneCards: FGF13
Gene ontology Molecular function • protein kinase activator activity • protein binding • growth factor activity • receptor binding • beta-tubulin binding • ion channel binding • microtubule binding • sodium channel regulator activity Cellular component • cytoplasm • cell projection • filopodium • growth cone • extracellular region • dendrite • nucleolus • microtubule • nucleus • plasma membrane • neuron projection • intercalated disc • axon Biological process • cell-cell signaling • nervous system development • MAPK cascade • signal transduction • neuron migration • learning • hippocampus development • protein localization to plasma membrane • negative regulation of microtubule depolymerization • activation of protein kinase activity • memory • establishment of neuroblast polarity • negative regulation of collateral sprouting • cerebral cortex cell migration • microtubule polymerization Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	2258	14168
Ensembl	ENSG00000129682	ENSMUSG00000031137
UniProt	Q92913	P70377
RefSeq (mRNA)	NM_001139498 NM_001139500 NM_001139501 NM_001139502 NM_004114 NM_033642	NM_001290414 NM_001290415 NM_010200
RefSeq (protein)	NP_001132970.1 NP_001132972.1 NP_001132973.1 NP_001132974.1 NP_004105.1 NP_378668.1	NP_001277344.1 NP_034330.2
Location (UCSC)	Chr X: 138.61 – 139.22 Mb	Chr X: 59.06 – 59.57 Mb
PubMed search	[1]	[2]
Wikidata

Fibroblast growth factor 13 is a protein that in humans is encoded by the FGF13 gene.^[3][4]

The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth, and invasion. This gene is located to a region associated with Borjeson-Forssman-Lehmann syndrome (BFLS), a syndromal X-linked mental retardation, which suggests it may be a candidate gene for familial cases of the BFL syndrome. The function of this gene has not yet been determined. Two alternatively spliced transcripts encoding different isoforms have been described for this gene.^[4]

References

Further reading