CNGB1

Identifiers

CNGB1, CNCG2, CNCG3L, CNCG4, CNG4, CNGB1B, GAR1, GARP, GARP2, RCNC2, RCNCb, RCNCbeta, RP45, cyclic nucleotide gated channel beta 1

External IDs

HomoloGene: 993 GeneCards: CNGB1

Gene ontology
Molecular function	• nucleotide binding • intracellular cyclic nucleotide activated cation channel activity • cyclic nucleotide-gated ion channel activity • cAMP binding • cGMP binding • protein binding • ligand-gated ion channel activity • voltage-gated potassium channel activity • intracellular cAMP activated cation channel activity • intracellular cGMP activated cation channel activity
Cellular component	• integral component of membrane • membrane • Golgi membrane • photoreceptor outer segment • ciliary membrane • Golgi-associated vesicle membrane • transmembrane transporter complex • terminal bouton • intracellular cyclic nucleotide activated cation channel complex • plasma membrane • integral component of plasma membrane
Biological process	• protein localization to organelle • response to stimulus • regulation of rhodopsin mediated signaling pathway • regulation of membrane potential • cation transport • ion transport • photoreceptor cell outer segment organization • cation transmembrane transport • detection of light stimulus involved in visual perception • sensory perception of smell • retina homeostasis • transport • photoreceptor cell maintenance • visual perception • rhodopsin mediated signaling pathway • phototransduction • regulation of cytosolic calcium ion concentration • potassium ion transmembrane transport • protein heterotetramerization
Sources:Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

Entrez


1258


n/a

Ensembl


ENSG00000070729


n/a

UniProt


Q14028


n/a

RefSeq (mRNA)


NM_001135639 NM_001286130 NM_001297


n/a

RefSeq (protein)


NP_001129111.1 NP_001273059.1 NP_001288.3


n/a

Location (UCSC)

Chr 16: 57.88 – 57.97 Mb

n/a

PubMed search

^[1]

n/a

Wikidata

View/Edit Human

Cyclic nucleotide gated channel beta 1, also known as CNGB1, is a human gene encoding an ion channel protein.^[2]

References

External links

GeneReviews/NCBI/NIH/UW entry on Retinitis Pigmentosa Overview
CNGB1 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)

Membrane transport protein: ion channels (TC 1A)

Ca²⁺: Calcium channel

Ligand-gated	Inositol trisphosphate receptor 1 2 3 Ryanodine receptor 1 2 3

Voltage-gated	L-type/Ca_vα 1.1 1.2 1.3 1.4 N-type/Ca_vα2.2 P-type/Ca_vα 2.1 Q-type/Ca_vα2.1 R-type/Ca_vα2.3 T-type/Ca_vα 3.1 3.2 3.3 α₂δ-subunits 1 2 β-subunits β1 β2 β3 β4 γ-subunits γ1 γ2 γ3 γ4 Cation channels of sperm 1 2 3 4 Two-pore channel 1 2

Na⁺: Sodium channel

Constitutively active	Epithelial sodium channel α β γ δ

Proton-gated	Amiloride-sensitive cation channel 1 2 3 4

Voltage-gated	Na_vα 1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 1.9 7A Na_vβ 1 2 3 4

K⁺: Potassium channel

Calcium-activated	BK channel α1 β1 β2 β3 β4 SK channel SK1 SK2 SK3 IK channel IK1 K_Ca 1.1 2.1 2.2 2.3 3.1 4.1 4.2 5.1

Inward-rectifier	K_ATP K_ir 1.1 2.1 2.2 2.3 2.4 2.6 GIRK/K_ir 3.1 3.2 3.3 3.4 K_ir 4.1 4.2 5.1 6.1 6.2 7.1

Tandem pore domain	K2P 1 2 3 4 5 6 7 9 10 12 13 15 16 17 18

Voltage-gated	K_vα1-6 1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 2.1 2.2 3.1 3.2 3.3 3.4 4.1 4.2 4.3 5.1 6.1 6.2 6.3 6.4 K_vα7-12 7.1 7.2 7.3 7.4 7.5 8.1 8.2 9.1 9.2 9.3 10.1 10.2 11.1/hERG 11.2 11.3 12.1 12.2 12.3 K_vβ 1 2 3 KCNIP 1 2 3 4 minK/ISK minK/ISK-like MiRP 1 2 3 Shaker gene

Miscellaneous

Cl⁻: Chloride channel	Calcium-activated chloride channels Anoctamin ANO1 Bestrophin 1 2 Chloride Channel Accessory 1 2 3 4 CFTR CLCN 1 2 3 4 5 6 7 KA KB CLIC 1 2 3 4 5 6 L1 CLNS 1A 1B

H⁺: Proton channel	HVCN1

M⁺: CNG cation channel	α 1 2 3 4 β 1 2 3 HCN FC 1 2 3 4

M⁺: TRP cation channel	TRPA (1) TRPC 1 2 3 4 4AP 5 6 7 TRPM 1 2 3 4 5 6 7 8 TRPML 1 2 3 TRPN TRPP 1 2 TRPV 1 2 3 4 5 6

H₂O (+ solutes): Porin	Aquaporin 0 1 2 3 4 5 6 7 8 9 Voltage-dependent anion channel 1 2 3 General bacterial porin family

Cytoplasm: Gap junction	Connexin: A GJA1 GJA3 GJA4 GJA5 GJA8 GJA9 GJA10 B GJB1 GJB2 GJB3 GJB4 GJB5 GJB6 GJB7 C GJC1 GJC2 GJC3 D GJD2 GJD3 GJD4) Innexin

By gating mechanism

Ion channel class	Ligand-gated Light-gated Voltage-gated Stretch-activated

see also disorders

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CNGB1

See also

References

Further reading

External links