| IUPAC name
(3α,5α,17β)-17-Hydroxyandrostan-3-yl β-D-glucopyranosiduronic acid
|3D model (Jmol)||Interactive image|
|Molar mass||468.59 g·mol−1|
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
3α-Androstanediol glucuronide (3α-ADG) is a metabolite formed from human androgens; compounds involved in the development and maintenance of sexual characteristics. It is formed by the glucuronidation of both dihydrotestosterone and testosterone, and has been proposed as means of measuring androgenic activity.
In women the adrenal steroids, dehydroepiandrosterone sulfate, androstenedione and dehydroepiandrosterone are the major precursors of plasma 3α-ADG, accounting for almost the totality of circulating 3α-ADG. Levels of 3α-ADG decrease significantly with age.
3α-ADG is used as a marker of target tissue cellular action. 3α-ADG correlates with level of 5α-reductase activity (testosterone and 3α-androstanediol to dihydrotestosterone) in the skin. Concentrations of 3α-ADG are associated with the level of cutaneous androgen metabolism.
- Moghissi E, Ablan F, Horton R (September 1984). "Origin of plasma androstanediol glucuronide in men". The Journal of Clinical Endocrinology and Metabolism. 59 (3): 417–21. doi:10.1210/jcem-59-3-417. PMID 6746859.
- Labrie, Fernand; Bélanger, Alain; Bélanger, Patrick; Bérubé, René; Martel, Céline; Cusan, Leonello; Gomez, José; Candas, Bernard; Castiel, Isabelle; Chaussade, Véronique; Deloche, Claire; Leclaire, Jacques (June 2006). "Androgen glucuronides, instead of testosterone, as the new markers of androgenic activity in women". The Journal of Steroid Biochemistry and Molecular Biology. 99 (4-5): 182–188. doi:10.1016/j.jsbmb.2006.02.004.
- Vermeulen A, Giagulli VA (November 1991). "Physiopathology of plasma androstanediol-glucuronide". The Journal of Steroid Biochemistry and Molecular Biology. 39 (5B): 829–33. doi:10.1016/0960-0760(91)90032-z. PMID 1835405.