IUPAC name
Other names
Molar mass 316.47758 g/mol
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Infobox references

3β-Dihydroprogesterone (3β-DHP), also known as 3β-hydroxyprogesterone or pregn-4-en-3β-ol-20-one (4-pregnenolone), is an endogenous steroid.[1] It is biosynthesized by 3β-hydroxysteroid dehydrogenase from progesterone. Unlike 3α-dihydroprogesterone, 3β-DHP does not act as a positive allosteric modulator of the GABAA,[1] which is in accordance with the fact that other 3β-hydroxylated progesterone metabolites such as isopregnanolone and epipregnanolone similarly do not act as potentiators of this receptor and instead inhibit it as well as reverse the effects of potentiators like allopregnanolone.[2]

See also


  1. 1 2 Kavaliers, Martin; Wiebe, John P.; Galea, Liisa A.M. (1994). "Reduction of predator odor-induced anxiety in mice by the neurosteroid 3α-hydroxy-4-pregnen-20-one (3αHP)". Brain Research. 645 (1-2): 325–329. doi:10.1016/0006-8993(94)91667-5. ISSN 0006-8993.
  2. Prince, R.J.; Simmonds, M.A. (1993). "Differential antagonism by epipregnanolone of alphaxalone and pregnanolone potentiation of [3H]flunitrazepam binding suggests more than one class of binding site for steroids at GABAA receptors". Neuropharmacology. 32 (1): 59–63. doi:10.1016/0028-3908(93)90130-U. ISSN 0028-3908.

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