Clinical data
Trade names Visudyne
AHFS/ Monograph
MedlinePlus a607060
  • US: C (Risk not ruled out)
Routes of
ATC code S01LA01 (WHO)
Legal status
Legal status
CAS Number 129497-78-5 YesY
PubChem (CID) 5362420
DrugBank DB00460 YesY
ChemSpider 21106402 YesY
UNII 0X9PA28K43 YesY
KEGG D01162 YesY
ChEBI CHEBI:60775 YesY
Chemical and physical data
Formula C41H42N4O8
Molar mass 718.794 g/mol
3D model (Jmol) Interactive image
 NYesY (what is this?)  (verify)

Verteporfin (trade name Visudyne), a benzoporphyrin derivative, is a medication used as a photosensitizer for photodynamic therapy to eliminate the abnormal blood vessels in the eye associated with conditions such as the wet form of macular degeneration. Verteporfin accumulates in these abnormal blood vessels and, when stimulated by nonthermal red light with a wavelength of 689 nm[1] in the presence of oxygen, produces highly reactive short-lived singlet oxygen and other reactive oxygen radicals, resulting in local damage to the endothelium and blockage of the vessels.[2][3]

Verteporfin is also used off-label for the treatment of central serous retinopathy.[4]


Verteporfin is given intravenously, 15 minutes before laser treatment.[2]



Side effects

Most common side effects are blurred vision, headache, and local effects at the injection site. Also, photosensitivity; it is advised to avoid exposure to sunlight and unscreened lighting until 48 hours after the injection of verteporfin.[2]


Verteporfin is known to interact with the herbal remedy feverfew (Tanacetum parthenium), the latter of which seems to act as an antagonist to verteporfin for unknown reasons. Taking the two substances simultaneously is inadvisable.[5]

Verteporfin has no influence on the liver enzyme CYP3A4, which metabolises many pharmaceutical drugs.[2]


  1. "Visudyne package insert" (PDF).
  2. 1 2 3 4 5 Verteporfin Monograph
  3. Scott, L. J.; Goa, K. L. (2000). "Verteporfin". Drugs & aging. 16 (2): 139–146; discussion 146–8. doi:10.2165/00002512-200016020-00005. PMID 10755329.
  4. Adelman, R.; Adelman, R. A. (2013). "Profile of verteporfin and its potential for the treatment of central serous chorioretinopathy". Clinical Ophthalmology. 7: 1867–1875. doi:10.2147/OPTH.S32177. PMC 3788817Freely accessible. PMID 24092965.
  5. "Feverfew and Verteporfin Interactions". Retrieved 14 April 2015.
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