IUPAC name
13010-20-3 N
3D model (Jmol) Interactive image
Interactive image
ChemSpider 94772 YesY
PubChem 105035
Molar mass 89.05 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Infobox references

Nitrosourea is both the name of a molecule, and a class of compounds that include a nitroso (R-NO) group and a urea.


Examples include:

Nitrosourea compounds are DNA alkylating agents and are often used in chemotherapy.[1] They are lipophilic and thus can cross the blood–brain barrier, making them useful in the treatment of brain tumors such as glioblastoma multiforme.[2]

Side effects

Some nitrosoureas (e.g. lomustine) have been associated with the development of interstitial lung disease.[3]


  1. "Antineop". Retrieved 2009-01-24.
  2. Takimoto CH, Calvo E. "Principles of oncologic pharmacotherapy". in Pazdur R, Wagman LD, Camphausen KA, Hoskins WJ (Eds) Cancer management: a multidisciplinary approach. 11 ed. 2008.
  3. Tucci E, Verdiani P, Di Carlo S, Sforza V (1986). "Lomustine (CCNU)-induced pulmonary fibrosis". Tumori. 72 (1): 95–8. PMID 3952821.
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