Clinical data
ATC code L01AD03 (WHO)
CAS Number 13909-09-6 YesY
PubChem (CID) 5198
ChemSpider 5009 N
UNII 6YY7T1T567 YesY
KEGG D05822 YesY
ECHA InfoCard 100.162.271
Chemical and physical data
Formula C10H18ClN3O2
Molar mass 247.72 g/mol
3D model (Jmol) Interactive image
 NYesY (what is this?)  (verify)

Semustine is a drug used in chemotherapy.[1] It is structurally similar to lomustine, being distinguished from it only by an additional methyl group. It has been taken off the drug market for investigation of its cancerous effects, rated as IARC Group 1 carcinogen or a known carcinogen.[2]


  1. "Radiation therapy and fluorouracil with or without semustine for the treatment of patients with surgical adjuvant adenocarcinoma of the rectum. Gastrointestinal Tumor Study Group". Journal of Clinical Oncology. 10 (4): 549–557. 1992. PMID 1548520.
  2., Known and Probable Human Carcinogens, American Cancer Society
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