Combination of
Perindopril ACE inhibitor
Indapamide Thiazide-like diuretic
Clinical data
Trade names Preterax, Noliprel
Routes of
Oral (tablets)
ATC code C09BA04 (WHO)
Legal status
Legal status
  • AU: S4 (Prescription only)
  • ℞ (Prescription only)
PubChem (CID) 9940214
ChemSpider 8115834 YesY

Perindopril/indapamide (marketed as Preterax and Noliprel) is a combination drug used for the treatment of essential hypertension.

Form and composition

Each scored tablet contains 2 mg of perindopril tert-butylamine salt and 0.625 mg of indapamide.


Essential hypertension.

Dosage and administration

One tablet daily, preferably to be taken in the morning and before a meal.

Elderly patients: Normal dosage.

Renal failure: Creatinine clearance (CrCl) >30 mL/min: no dosage modification. If CrCl <30 mL/min, treatment is contraindicated.

Pharmacological action

Using a fixed combination of an ACE inhibitor and a chlorosulfamoyl diuretic leads to additive synergy of the antihypertensive effects of the two constituents. Its pharmacological properties are derived from those of each of the components taken separately, in addition to those due to the additive synergistic action of the two constituents, when combined, on vascular endothelium, arteriolocapillary microcirculation, and the target organs of hypertension.


Absolute: Known allergy to perindopril, indapamide, or sulfonamides; history of Quincke's edema linked to previous ACE inhibitor therapy; end-stage renal disease; serious liver disorder; hyperkalemia; pregnancy; lactation. Relative: Combination therapy with lithium, potassium salts, potassium-sparing diuretics, and certain medicines which can cause heart rhythm disorders.

Side effects

Asthenia, dizziness, headache, mood swings and/or sleep disturbances, cramps, hypotension, allergic reactions, skin rashes, gastrointestinal disorders, dry cough, erectile dysfunctions, dry mouth, risk of dehydration in the elderly and in patients suffering from heart failure, sexual dysfunctions; changes in blood test results may occur.


Immunosuppressed patients. Hemodialysis: risk of anaphylactoid reaction during hemodialysis with polyacrylonitrile membranes. Liver impairment.


Disorders of electrolyte balance, diabetes, gout, hypotension, or strict sodium-free diets, heart or renal failure, atherosclerosis, renal artery stenosis, elderly.

Drug interactions

Not recommended: combinations with lithium, potassium-sparing diuretics, potassium (salts), antiarrhythmic drugs which can cause torsades de pointes, anesthetic drugs, cytostatics or immunosuppressive agents.

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