|AHFS/Drugs.com||International Drug Names|
|ATC code||C09AA12 (WHO)|
|Chemical and physical data|
|Molar mass||452.542 g/mol|
|3D model (Jmol)||Interactive image|
|(what is this?)|
Delapril (INN, also known as alindapril) is an ACE inhibitor used as an antihypertensive drug in some European and Asian countries but not in America. It is taken orally, available in 15mg and 30mg tablets.
Delapril is a prodrug; it is converted into two active metabolites, 5-hydroxy delapril diacid and delapril diacid. These metabolites bind completely to and inhibit angiotensin-converting enzyme (ACE), hence blocking angiotensin I to angiotensin II conversion. The resulting vasodilation prevents the vasoconstrictive effects of angiotensin II. Angiotensin II-induced aldosterone secretion by the adrenal cortex is also decreased by Delapril, leading to increases in excretion of sodium and therefore increases water outflow.
- Otero, M. L. (2007). "Manidipine-delapril combination in the management of hypertension". Vascular health and risk management. 3 (3): 255–263. PMC 2293964. PMID 17703633.
- Drugs.com: Delapril
- "http://cursoenarm.net/UPTODATE/contents/mobipreview.htm?16/0/16396?source=HISTORY". cursoenarm.net. Retrieved 2016-08-28. External link in
- Pubchem. "DELAPRIL | C26H32N2O5 - PubChem". pubchem.ncbi.nlm.nih.gov. Retrieved 2016-08-28.