Delapril

Delapril
Clinical data

AHFS/Drugs.com	International Drug Names
ATC code	C09AA12 (WHO)
Identifiers
IUPAC name 2-[2,3-dihydro-1H-inden-2-yl-[(2S)-2-[[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino]propanoyl]amino]acetic acid
CAS Number	83435-66-9^Y
PubChem (CID)	5362116
ChemSpider	4514931^N
UNII	W77UAL9THI^Y
KEGG	D07781^Y
ChEMBL	CHEMBL2106126^N
Chemical and physical data
Formula	C₂₆H₃₂N₂O₅
Molar mass	452.542 g/mol
3D model (Jmol)	Interactive image
SMILES O=C(OCC)[C@@H](N[C@H](C(=O)N(CC(=O)O)C2Cc1ccccc1C2)C)CCc3ccccc3
InChI InChI=1S/C26H32N2O5/c1-3-33-26(32)23(14-13-19-9-5-4-6-10-19)27-18(2)25(31)28(17-24(29)30)22-15-20-11-7-8-12-21(20)16-22/h4-12,18,22-23,27H,3,13-17H2,1-2H3,(H,29,30)/t18-,23-/m0/s1^N Key:WOUOLAUOZXOLJQ-MBSDFSHPSA-N^N
^NY (what is this?) (verify)

Delapril (INN, also known as alindapril) is an ACE inhibitor used as an antihypertensive drug^[1] in some European and Asian countries but not in America.^[2] It is taken orally, available in 15mg and 30mg tablets.^[3]

Mechanism

Delapril is a prodrug; it is converted into two active metabolites, 5-hydroxy delapril diacid and delapril diacid. These metabolites bind completely to and inhibit angiotensin-converting enzyme (ACE), hence blocking angiotensin I to angiotensin II conversion. The resulting vasodilation prevents the vasoconstrictive effects of angiotensin II. Angiotensin II-induced aldosterone secretion by the adrenal cortex is also decreased by Delapril, leading to increases in excretion of sodium and therefore increases water outflow.^[4]

References

↑ Otero, M. L. (2007). "Manidipine-delapril combination in the management of hypertension". Vascular health and risk management. 3 (3): 255–263. PMC 2293964. PMID 17703633.
↑ Drugs.com: Delapril
↑ "http://cursoenarm.net/UPTODATE/contents/mobipreview.htm?16/0/16396?source=HISTORY". cursoenarm.net. Retrieved 2016-08-28. External link in |title= (help)
↑ Pubchem. "DELAPRIL | C26H32N2O5 - PubChem". pubchem.ncbi.nlm.nih.gov. Retrieved 2016-08-28.

Antihypertensives: agents acting on the renin–angiotensin system (C09)

ACE inhibitors ("-pril")	Sulfhydryl-containing: Captopril Rentiapril Zofenopril Dicarboxylate-containing: Enalapril^# Benazepril Cilazapril Delapril Imidapril Lisinopril (+HCT) Moexipril Perindopril (+indapamide) Quinapril (+HCT) Ramipril Spirapril Temocapril Trandolapril Phosphonate-containing: Fosinopril (+HCT) Other/ungrouped: Alacepril

AIIRAs ("-sartan")	Azilsartan Candesartan Eprosartan Fimasartan Irbesartan Losartan (+HCT) Olmesartan (+amlodipine) Tasosartan^§ Telmisartan (+HCT) Valsartan (+HCT, +amlodipine, +sacubitril)

Renin inhibitors ("-kiren")	Aliskiren (+amlodipine, +amlodipine and HCT) Remikiren^§

^#WHO-EM ^‡Withdrawn from market Clinical trials: ^†Phase III ^§Never to phase III

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