|Trade names||Fraxiparine, Fraxodi|
|AHFS/Drugs.com||International Drug Names|
|SC (except for haemodialysis)|
|ATC code||B01AB06 (WHO)|
|Bioavailability||89% (SC dose)|
|Biological half-life||3.7 hours (SC dose)|
|Excretion||clearance 21.4mL/min (+/- 7)|
|Chemical and physical data|
|Molar mass||4300 g/mol|
|(what is this?)|
Nadroparin (trade name, Fraxiparine or Fraxodi) is an anticoagulant belonging to a class of drugs called low molecular weight heparins (LMWHs). Nadroparin was developed by sanofi-synthelabo.
Nadroparin is used in general and orthopedic surgery to prevent thromboembolic disorders (deep vein thrombosis and pulmonary embolism), and as treatment for deep vein thrombosis. It is also used to prevent clotting during hemodialysis, and for treatment of unstable angina and non-Q wave myocardial infarction.
For the treatment and prevention of DVT, the drug is administered as a subcutaneous injection (under the skin), usually around the stomach. Injections are given once or twice daily depending on the condition.
- Fraxiparine PRODUCT MONOGRAPH (Canada); http://www.aspripharma.com/pdf/Fraxiparine%20&%20Fraxi%20Forte%20PM_EN.pdf
- Shafiq N, Malhotra S, Pandhi P, Sharma N, Bhalla A, Grover A (2006). "A randomized controlled clinical trial to evaluate the efficacy, safety, cost-effectiveness and effect on PAI-1 levels of the three low-molecular-weight heparins--enoxaparin, nadroparin and dalteparin. The ESCAPe-END study". Pharmacology. 78 (3): 136–43. doi:10.1159/000096484. PMID 17057417.