Glycoprotein IIb/IIIa inhibitors
Several GpIIb/IIIa inhibitors exist:
They may also be used to treat acute coronary syndromes, without percutaneous coronary intervention, depending on TIMI risk.
They should be given intravenously. The oral form is associated with increased mortality and hence should not be given.
In integrin nomenclature glycoprotein IIb/IIIa is called αIIbβ3.
Their development arose from the understanding of Glanzmann's thrombasthenia, a condition in which the GpIIb/IIIa is lacking.
- Seligsohn U. Glanzmann thrombasthenia: a model disease which paved the way to powerful therapeutic agents. Pathophysiol Haemost Thromb. 2002 Sep-Dec;32(5-6):216-7. doi:10.1159/000073569 PMID 13679645. Free Full Text.