Clinical data
Trade names Eminase
AHFS/ Micromedex Detailed Consumer Information
ATC code B01AD03 (WHO)
Pharmacokinetic data
Biological half-life 90 minutes
CAS Number 81669-57-0 YesY
DrugBank DB00029 YesY
ChemSpider none
KEGG D02947 YesY
Chemical and physical data
Molar mass approx. 131 kg/mol

Anistreplase is a thrombolytic drug.[1][2][3]

Anistreplase has been developed by Beecham as Eminase. It is also known as anisoylated plasminogen streptokinase activator complex (APSAC)


It is a complex of purified human plasminogen and bacterial streptokinase that has been acylated to protect the enzyme's active site. When the drug is administered, the acyl group gets hydrolyzed, thereby freeing the activator complex. It converts plasminogen to plasmin, which in turn degrades fibrin (blood clots) to fibrin split products.


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