|Synonyms||HT-0712, IPL 455,903|
|Chemical and physical data|
|Molar mass||393.53 g/mol|
|3D model (Jmol)||Interactive image|
HT-0712 also known as IPL-455903, is an experimental cognitive enhancing drug (nootropic) which is currently undergoing clinical trials. It is currently being licensed by Helicon Therapeutics in San Diego, California. It was originally discovered and tested as part of a preclinical anti-inflammatory program by Inflazyme Pharmaceuticals.
Mechanism of action
HT-0712 appears to act as a PDE4 inhibitor, thereby increasing cAMP levels. When cAMP levels are increased in neurons, this may trigger activation of cAMP response element-binding proteins (CREB). CREBs are transcription factors involved in the formation of long-term memory.
The side effects of the drug are not yet fully known.
- Giembycz MA (October 2008). "Can the anti-inflammatory potential of PDE4 inhibitors be realized: guarded optimism or wishful thinking?". Br. J. Pharmacol. 155 (3): 288–90. doi:10.1038/bjp.2008.297. PMC 2567889. PMID 18660832.
- MacDonald E, Van der Lee H, Pocock D, et al. (2007). "A novel phosphodiesterase type 4 inhibitor, HT-0712, enhances rehabilitation-dependent motor recovery and cortical reorganization after focal cortical ischemia". Neurorehabil Neural Repair. 21 (6): 486–96. doi:10.1177/1545968307305521. PMID 17823313.
- "The PDE4 inhibitor HT-0712 improves hippocampus-dependent memory in aged mice". Retrieved 18 October 2015.