Clinical data
AHFS/ International Drug Names
Routes of
ATC code R03DA11 (WHO)
Legal status
Legal status
  • ℞ (Prescription only)
CAS Number 69975-86-6 YesY
PubChem (CID) 50942
DrugBank DB09273
ChemSpider 46175
KEGG D03898 YesY
ECHA InfoCard 100.067.468
Chemical and physical data
Formula C11H14N4O4
Molar mass 266.25 g/mol
3D model (Jmol) Interactive image

Doxofylline (also known as doxophylline) is a xanthine derivative drug used in the treatment of asthma.[1]

It has antitussive and bronchodilator[2] effects, and acts as a phosphodiesterase inhibitor.[3]

In animal and human studies, it has shown similar efficacy to theophylline but with significantly fewer side effects.[4]

Unlike other xanthines, doxofylline lacks any significant affinity for adenosine receptors and does not produce stimulant effects. This suggests that its antiasthmatic effects are mediated by another mechanism, perhaps its actions on phosphodiesterase.[1]

Doxofylline is available under the trade name Filodox in Bangladesh


  1. 1 2 Cirillo R, Barone D, Franzone JS (1988). "Doxofylline, an antiasthmatic drug lacking affinity for adenosine receptors". Arch Int Pharmacodyn Ther. 295: 221–37. PMID 3245738.
  2. Poggi R, Brandolese R, Bernasconi M, Manzin E, Rossi A (October 1989). "Doxofylline and respiratory mechanics. Short-term effects in mechanically ventilated patients with airflow obstruction and respiratory failure". Chest. 96 (4): 772–8. doi:10.1378/chest.96.4.772. PMID 2791671.
  3. Dini FL, Cogo R (2001). "Doxofylline: a new generation xanthine bronchodilator devoid of major cardiovascular adverse effects". Curr Med Res Opin. 16 (4): 258–68. doi:10.1185/030079901750120196. PMID 11268710.
  4. Sankar J, Lodha R, Kabra SK (March 2008). "Doxofylline: The next generation methylxanthine". Indian J Pediatr. 75 (3): 251–4. doi:10.1007/s12098-008-0054-1. PMID 18376093.

Further reading

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