Sangassou virus

Sangassou virus
Virus classification
Group: Group V ((-)ssRNA)
Order: Unassigned
Family: Bunyaviridae
Genus: Hantavirus
Species: Sangassou virus

Sangassou virus (SANGV) is single-stranded, negative-sense DNA virus species of the genus hantavirus in the Bunyaviridae family. It was first isolated in an African wood mouse (Hylomyscus simus) in the forest in Guinea, West Africa in 2010. It is named for the village near where the mouse was trapped. It is the first indigenous Murinae-associated African hantavirus to be discovered.[1]

Genome

The virus genome consists of three segments of negative-stranded RNA; the large (L) segment encodes the viral RNA-dependent RNA polymerase, the medium (M) segment encodes the envelope glycoproteins Gn and Gc (cotranslationally cleaved from a glycoprotein precursor), and the small (S) segment encodes the nucleocapsid (N) protein.[1]

Renal syndrome

In rodents, hantavirus produces a chronic infection with no adverse sequelae. In humans, hantavirus produces two major clinical syndromes: hemorrhagic fever or pulmonary syndrome. European, Asian, and African rodent-borne hantaviruses cause hemorrhagic fever. The pulmonary syndrome, caused by the species Sin Nombre virus, has not been found anywhere other than the United States where deer mice are the natural hosts. It was discovered in 1993 during an outbreak in the Four Corners region of the southwestern United States.[2][3]

Reservoirs

Natural reservoirs for this hantavirus species include the split faced bat, moles, and shrews. Rodent-borne hantaviruses form three major evolutionary clades corresponding to the subfamilies of their rodent hosts. HTNV, SEOV, and DOBV are examples of Murinae-associated hantaviruses. PUUV and Tula virus (TULV) belong to the Arvicolinae-associated hantaviruses, and SNV and ANDV are representatives of Neotominae- and Sigmodontinae-associated hantaviruses.[1][4]

See also

References

  1. 1 2 3 Klempa, B.; Witkowski, P. T.; Popugaeva, E.; Auste, B.; Koivogui, L.; Fichet-Calvet, E.; Strecker, T.; Ter Meulen, J.; Krüger, D. H. (2012). "Sangassou Virus, the First Hantavirus Isolate from Africa, Displays Genetic and Functional Properties Distinct from Those of Other Murinae-Associated Hantaviruses". Journal of Virology. 86 (7): 3819–3827. doi:10.1128/JVI.05879-11. PMC 3302504Freely accessible. PMID 22278233.
  2. ↑ "CDC - Hemorrhagic Fever with Renal Syndrome (HFRS) - Hantavirus". Cdc.gov. 2011-05-17. Retrieved 2013-04-13.
  3. ↑ Peters CJ, Simpson GL, Levy H (1999). "Spectrum of hantavirus infection: hemorrhagic fever with renal syndrome and hantavirus pulmonary syndrome". Annu. Rev. Med. 50: 531–45. doi:10.1146/annurev.med.50.1.531. PMID 10073292.
  4. ↑ Klempa, B.; Fichet-Calvet, E.; Lecompte, E.; Auste, B.; Aniskin, V.; Meisel, H.; Barrière, P.; Koivogui, L.; Ter Meulen, J.; Krüger, D. H. (2007). "Novel Hantavirus Sequences in Shrew, Guinea". Emerging Infectious Diseases. 13 (3): 520–522. doi:10.3201/eid1303.061198. PMC 2725914Freely accessible. PMID 17554814.
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