SPTBN5
| SPTBN5 | ||||||
|---|---|---|---|---|---|---|
| Identifiers | ||||||
| Aliases | SPTBN5, BSPECV, HUBSPECV, HUSPECV, spectrin beta, non-erythrocytic 5 | |||||
| External IDs | MGI: 2685200 HomoloGene: 41150 GeneCards: SPTBN5 | |||||
| Orthologs | ||||||
| Species | Human | Mouse | ||||
| Entrez | ||||||
| Ensembl | ||||||
| UniProt |
| |||||
| RefSeq (mRNA) | ||||||
| RefSeq (protein) |
| |||||
| Location (UCSC) | Chr 15: 41.85 – 41.89 Mb | n/a | ||||
| PubMed search | [1] | [2] | ||||
| Wikidata | ||||||
| View/Edit Human | View/Edit Mouse |
Spectrin, beta, non-erythrocytic 5 also known as SPTBN5 is a protein that in humans is encoded by the SPTBN5 gene.[3] SPTBN5 belongs to the spectrin family of cytoskeletal proteins.
Structure and function
SPTBN5 contains the following domains:[3]
- actin-binding domain
- membrane-association domain-1
- self-association domain
- C-terminal pleckstrin homology domain.
Based on these structural features it is thought that SPTBN5 is likely to form heterodimers and oligomers with alpha-spectrin and to interact directly with cellular membranes.[3]
SPTBN5 is highly expressed in embryoid bodies.[4]
References
- ↑ "Human PubMed Reference:".
- ↑ "Mouse PubMed Reference:".
- 1 2 3 Stabach PR, Morrow JS (July 2000). "Identification and characterization of beta V spectrin, a mammalian ortholog of Drosophila beta H spectrin". J. Biol. Chem. 275 (28): 21385–95. doi:10.1074/jbc.C000159200. PMID 10764729.
- ↑ Chaerkady R, Kerr CL, Marimuthu A, Kelkar DS, Kashyap MK, Gucek M, Gearhart JD, Pandey A (January 2009). "Temporal analysis of neural differentiation using quantitative proteomics". J. Proteome Res. 8 (3): 1315–26. doi:10.1021/pr8006667. PMC 2693473
. PMID 19173612.
Further reading
- Odell AF, Van Helden DF, Scott JL (2008). "The spectrin cytoskeleton influences the surface expression and activation of human transient receptor potential channel 4 channels". J. Biol. Chem. 283 (7): 4395–407. doi:10.1074/jbc.M709729200. PMID 18048348.
- Oguri M, Kato K, Yokoi K, et al. (2010). "Assessment of a polymorphism of SDK1 with hypertension in Japanese Individuals". Am. J. Hypertens. 23 (1): 70–7. doi:10.1038/ajh.2009.190. PMID 19851296.
- Shoeman RL, Hartig R, Hauses C, Traub P (2002). "Organization of focal adhesion plaques is disrupted by action of the HIV-1 protease". Cell Biol. Int. 26 (6): 529–39. doi:10.1006/cbir.2002.0895. PMID 12119179.
- Chardin P, Camonis JH, Gale NW, et al. (1993). "Human Sos1: a guanine nucleotide exchange factor for Ras that binds to GRB2". Science. 260 (5112): 1338–43. doi:10.1126/science.8493579. PMID 8493579.
This article is issued from Wikipedia - version of the 6/3/2016. The text is available under the Creative Commons Attribution/Share Alike but additional terms may apply for the media files.