Keratin 3

KRT3
Identifiers
Aliases KRT3, CK3, K3, keratin 3
External IDs OMIM: 148043 HomoloGene: 130909 GeneCards: KRT3
Orthologs
Species Human Mouse
Entrez

3850

n/a

Ensembl

ENSG00000186442

n/a

UniProt

P12035

n/a

RefSeq (mRNA)

NM_057088

n/a

RefSeq (protein)

NP_476429.2

n/a

Location (UCSC) Chr 12: 52.79 – 52.8 Mb n/a
PubMed search [1] n/a
Wikidata
View/Edit Human

Keratin 3 also known as cytokeratin 3 is a protein that in humans is encoded by the KRT3 gene.[2][3] Keratin 3 is a type II cytokeratin. It is specifically found in the corneal epithelium together with keratin 12.

Mutations in the KRT3 encoding this protein have been associated with Meesmanns Corneal Dystrophy.[4]

References

  1. ↑ "Human PubMed Reference:".
  2. ↑ Raimondi E, Moralli D, De Carli L, Ceratto N, Balzaretti M, Leube R, Collin C, Romano V (1994). "Assignment of the human cytokeratin 3 gene (KRT3) to 12q12-->q13 by FISH". Cytogenet. Cell Genet. 66 (3): 162–3. doi:10.1159/000133690. PMID 7510223.
  3. ↑ Schweizer J, Bowden PE, Coulombe PA, Langbein L, Lane EB, Magin TM, Maltais L, Omary MB, Parry DA, Rogers MA, Wright MW (July 2006). "New consensus nomenclature for mammalian keratins". J. Cell Biol. 174 (2): 169–74. doi:10.1083/jcb.200603161. PMC 2064177Freely accessible. PMID 16831889.
  4. ↑ Irvine AD, Corden LD, Swensson O, Swensson B, Moore JE, Frazer DG, Smith FJ, Knowlton RG, Christophers E, Rochels R, Uitto J, McLean WH (June 1997). "Mutations in cornea-specific keratin K3 or K12 genes cause Meesmann's corneal dystrophy". Nat. Genet. 16 (2): 184–7. doi:10.1038/ng0697-184. PMID 9171831.


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