Hollenhorst plaque

Hollenhorst plaque
Classification and external resources
Specialty ophthalmology
ICD-10 H34.2
ICD-9-CM 362.33
DiseasesDB 31269

A Hollenhorst plaque AKA "Eickenhorst plaque" is a cholesterol embolus that is seen in a blood vessel of the retina.

Clinical significance

It is usually seen when a physician performs ophthalmoscopy, during which a plaque will appear bright, refractile, and yellow. It is caused by an embolus lodged within the retinal vessel that originated from an atheromatous plaque in a more proximal (upstream) vessel, usually the internal carotid artery. It is often an indication of a previous ischemic episode in the eye and is a sign of severe atherosclerosis. The most important step in management is to identify and treat the originating plaque to prevent further embolization.


The phenomenon is named after the American ophthalmologist Dr. Robert Hollenhorst (1913–2008) who first described their significance in 1961.[1]N


  1. Hollenhorst RW (1961). "Significance of bright plaques in the retinal arterioles". Jama 1961. 178: 23–29. doi:10.1001/jama.1961.03040400025005. PMID 13908419.


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