Glycerophosphodiester phosphodiesterase
| glycerophosphodiester phosphodiesterase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 3.1.4.46 | ||||||||
| CAS number | 86280-59-3 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / EGO | ||||||||
| |||||||||
In enzymology, a glycerophosphodiester phosphodiesterase (EC 3.1.4.46) is an enzyme that catalyzes the chemical reaction
- a glycerophosphodiester + H2O an alcohol + sn-glycerol 3-phosphate
Thus, the two substrates of this enzyme are glycerophosphodiester and H2O, whereas its two products are alcohol and sn-glycerol 3-phosphate.
This enzyme belongs to the family of hydrolases, specifically those acting on phosphoric diester bonds. The systematic name of this enzyme class is glycerophosphodiester glycerophosphohydrolase. Other names in common use include gene hpd protein, glycerophosphoryl diester phosphodiesterase, and IgD-binding protein D. This enzyme participates in glycerophospholipid metabolism.
Structural studies
As of late 2007, 9 structures have been solved for this class of enzymes, with PDB accession codes 1O1Z, 1T8Q, 1V8E, 1VD6, 1YDY, 2DXL, 2DXN, 2OOG, and 2P76.
References
- Larson TJ, Ehrmann M, Boos W (1983). "Periplasmic glycerophosphodiester phosphodiesterase of Escherichia coli, a new enzyme of the glp regulon". J. Biol. Chem. 258 (9): 5428–32. PMID 6304089.