Ribonuclease E
| Ribonuclease E | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 3.1.26.12 | ||||||||
| CAS number | 76106-82-6 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
Ribonuclease E (EC 3.1.26.12, endoribonuclease E, RNase E, Rne protein) is an enzyme.[1][2][3][4][5][6] This enzyme catalyses the following chemical reaction
- Endonucleolytic cleavage of single-stranded RNA in A- and U-rich regions
RNase E is a bacterial ribonuclease that participates in the processing of ribosomal RNA (9S to 5S rRNA) and the chemical degradation of bulk cellular RNA.
References
- ↑ Feng, Y.; Vickers, T.A.; Cohen, S.N. (2002). "The catalytic domain of RNase E shows inherent 3′ to 5′ directionality in cleavage site selection". Proc. Natl. Acad. Sci. USA. 99 (23): 14746–14751. doi:10.1073/pnas.202590899. PMC 137490
. PMID 12417756. - ↑ Ehretsmann, C.P.; Carpousis, A.J.; Krisch, H.M. (1992). "Specificity of Escherichia coli endoribonuclease RNase E: in vivo and in vitro analysis of mutants in a bacteriophage T4mRNA processing site". Genes Dev. 6 (1): 149–159. doi:10.1101/gad.6.1.149. PMID 1730408.
- ↑ Cormack, R.S.; Genereaux, J.L.; Mackie, G.A. (1993). "RNase E activity is conferred by a single polypeptide: overexpression, purification, and properties of the ams/rne/hmp1 gene product". Proc. Natl. Acad. Sci. USA. 90 (19): 9006–9010. doi:10.1073/pnas.90.19.9006. PMC 47490. PMID 8415644.
- ↑ Vanzo, N.F.; Li, Y.S.; Py, B.; Blum, E.; Higgins, C.F.; Raynal, L.C.; Krisch, H.M.; Carpousis, A.J. (1998). "Ribonuclease E organizes the protein interactions in the Escherichia coli RNA degradosome". Genes Dev. 12 (17): 2770–2781. doi:10.1101/gad.12.17.2770. PMC 317140. PMID 9732274.
- ↑ Steege, D.A. (2000). "Emerging features of mRNA decay in bacteria". RNA. 6 (8): 1079–1090. doi:10.1017/S1355838200001023. PMC 1369983. PMID 10943888.
- ↑ Callaghan, A.J.; Grossmann, J.G.; Redko, Y.U.; Ilag, L.L.; Moncrieffe, M.C.; Symmons, M.F.; Robinson, C.V.; McDowall, K.J.; Luisi, B.F. (2003). "Quaternary structure and catalytic activity of the Escherichia coli ribonuclease E amino-terminal catalytic domain". Biochemistry. 42 (47): 13848–13855. doi:10.1021/bi0351099. PMID 14636052.
External links
- Ribonuclease E at the US National Library of Medicine Medical Subject Headings (MeSH)
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