Complement component 1s

complement component 1, s subcomponent
Identifiers
Symbol	C1S
Entrez	716
HUGO	1247
OMIM	120580
RefSeq	NM_001734
UniProt	P09871
Other data
EC number	3.4.21.42
Locus	Chr. 12 p13

Complement component 1S (EC 3.4.21.42, C1 esterase, activated complement C1s, complement C overbar 1r ) is a protein involved in the complement system.^[1]^[2]^[3]^[4]

C1s cleaves C4, which eventually leads to the production of the C4b-C2a form of C3-convertase.

Classical pathway. (Some labels are in Polish.)

References

↑ Sim, R.B. (1981). "The human complement system serine proteases C^1r and C^1s and their proenzymes". Methods Enzymol. 80: 26–42. doi:10.1016/s0076-6879(81)80006-7. PMID 6281620.
↑ MacKinnon, C.M.; Carter, P.E.; Smyth, S.J.; Dunbar, B.; Fothergill, J.E. (1987). "Molecular cloning of cDNA for human complement component C1s. The complete amino acid sequence". Eur. J. Biochem. 169: 547–553. doi:10.1111/j.1432-1033.1987.tb13644.x. PMID 3500856.
↑ Müller-Eberhard, H.J. (1988). "Molecular organization and function of the complement system". Annu. Rev. Biochem. 57: 321–347. doi:10.1146/annurev.bi.57.070188.001541. PMID 3052276.
↑ Skoog, M.T.; Mehdi, S.; Wiseman, J.S.; Bey, P. (1989). "The specificity of two proteinases that cleave adjacent to arginine, C1 esterase and acrosin, for peptide p-nitroanilide substrates". Biochim. Biophys. Acta. 996 (1-2): 89–94. doi:10.1016/0167-4838(89)90099-x. PMID 2500154.

Complement C1s at the US National Library of Medicine Medical Subject Headings (MeSH)

Activators/enzymes

Early	C: C1Q/C1R/C1S C4 C4a C4b C2 L: MASP1/MASP2 MBL A: Factor B Factor D Factor P/Properdin

Middle	C3 C3a C3b/iC3b C5 C5a C3-convertase C5-convertase

Late	MAC C6 C7 C8 C9

Inhibitors

Endopeptidases: serine proteases/serine endopeptidases (EC 3.4.21)

Digestive enzymes	Enteropeptidase Trypsin Chymotrypsin Elastase Neutrophil Pancreatic

Coagulation	factors: Thrombin Factor VIIa Factor IXa Factor Xa Factor XIa Factor XIIa Kallikrein PSA KLK1 KLK2 KLK3 KLK4 KLK5 KLK6 KLK7 KLK8 KLK9 KLK10 KLK11 KLK12 KLK13 KLK14 KLK15 fibrinolysis: Plasmin Plasminogen activator Tissue plasminogen activator Urinary plasminogen activator

Complement system	Factor B Factor D Factor I MASP MASP1 MASP2 C3-convertase

Other immune system	Chymase Granzyme Tryptase Proteinase 3/Myeloblastin

Venombin	Ancrod Batroxobin

Other	Acrosin Prolyl endopeptidase Pronase Proprotein convertases 1 2 Prostasin Reelin Subtilisin/Furin Streptokinase S1P Cathepsin A G

Enzymes

Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Catalytically perfect enzyme Coenzyme Cofactor Enzyme catalysis Enzyme kinetics Lineweaver–Burk plot Michaelis–Menten kinetics

Regulation	Allosteric regulation Cooperativity Enzyme inhibitor

Classification	EC number Enzyme superfamily Enzyme family List of enzymes

Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list)

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