Clinical data
ATC code S01CA09 (WHO) (combination with antiinfectives)
Synonyms 6α-Chloro-1,4-pregnadiene-17a,21-diol-3,11,20-trione
CAS Number 52080-57-6
PubChem (CID) 3034026
ChemSpider 2298578
ECHA InfoCard 100.052.387
Chemical and physical data
Formula C21H25ClO5
Molar mass 392.873 g/mol
3D model (Jmol) Interactive image

Chloroprednisone is a topical glucocorticoid first reported in 1960.[1] It is a chlorinated derivative of prednisone. The acetate ester prodrug, chloroprednisone 21-acetate, was sold under the brand name Topilan as an anti-inflammatory agent.[2][3]

There is little published about chloroprednisone. This may be due to limited activity topically because the skin lacks the necessary activating enzyme 11-Beta hydroxysteroid dehydrogenase. Systemically, this agent's activity on Glucocorticoid receptors may not have competed with agents like Fludrocortisone or Dexamethasone.


  1. Batres, Enrique; Bowers, Albert; Djerassi, Carl; Kincl, Fred A.; Mancera, Octavio; Ringold, Howard J.; Rosenkranz, Jorge; Zaffaroni, Alejandro. 6α-Chloro- or 6α-fluoro-1,4-pregnadiene-3,20-diones. (1960) DE 1079042
  2. Merck Index, 11th Edition, 2157
  3. A. D. Roberts (1991). Dictionary of Steroids: Chemical Data, Structures, and Bibliographies. 1. CRC Press. p. 108.

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