Difluocortolone valerate

Difluocortolone valerate
IUPAC name
(6α,11β,16α)-6,9-Difluoro-11-hydroxy-16-methyl-3,20-dioxopregna-1,4-dien-21-yl pentanoate
Other names
Afusona; Diflucortolone 21-valerate
59198-70-8 YesY
3D model (Jmol) Interactive image
ChemSpider 82773 YesY
ECHA InfoCard 100.056.032
PubChem 91670
Molar mass 478.58 g·mol−1
Melting point 220 °C (428 °F; 493 K)[1]
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Infobox references

Difluocortolone valerate (also Nerisone cream/oily cream/ointment, Neriderm ointment, Japanese ジフルコルトロン (Jifurucorutoron) is a corticosteroid rated Class 2 "potent" (100-150 times) in the New Zealand topical steroid system. It is a white to creamy white crystalline powder. It is practically insoluble in water, freely soluble in dichloromethane and in dioxan, sparingly soluble in ether and slightly soluble in methyl alcohol. Chemically, it is a corticosteroid esterified with valeric acid. It is commonly used topically in dermatology. The brand name is Nerisone; its creams come in potencies of 0.1% and 0.3%.

See also


This article is issued from Wikipedia - version of the 11/1/2015. The text is available under the Creative Commons Attribution/Share Alike but additional terms may apply for the media files.