Aliases ABCF2, ABC28, EST133090, HUSSY18, HUSSY-18, ATP binding cassette subfamily F member 2
External IDs MGI: 1351657 HomoloGene: 21408 GeneCards: ABCF2
RNA expression pattern

More reference expression data
Species Human Mouse









RefSeq (mRNA)



RefSeq (protein)



Location (UCSC) Chr 7: 151.21 – 151.23 Mb Chr 5: 24.57 – 24.58 Mb
PubMed search [1] [2]
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ATP-binding cassette sub-family F member 2 is a protein that in humans is encoded by the ABCF2 gene.[3][4]


The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, and White). This protein is a member of the GCN20 subfamily. Alternative splicing of this gene results in multiple transcript variants.[4]

ABCF2 acts as a suppressor of the volume-sensitive outwardly rectifying Cl channel (CLCN3).[5]

See also


  1. "Human PubMed Reference:".
  2. "Mouse PubMed Reference:".
  3. Allikmets R, Gerrard B, Hutchinson A, Dean M (October 1996). "Characterization of the human ABC superfamily: isolation and mapping of 21 new genes using the expressed sequence tags database". Human Molecular Genetics. 5 (10): 1649–55. doi:10.1093/hmg/5.10.1649. PMID 8894702.
  4. 1 2 "Entrez Gene: ABCF2 ATP-binding cassette, sub-family F (GCN20), member 2".
  5. Ando-Akatsuka Y, Shimizu T, Numata T, Okada Y (2012). "Involvements of the ABC protein ABCF2 and α-actinin-4 in regulation of cell volume and anion channels in human epithelial cells". Journal of Cellular Physiology. 227 (10): 3498–510. doi:10.1002/jcp.24050. PMID 22252987.

Further reading

  • Klein I, Sarkadi B, Váradi A (December 1999). "An inventory of the human ABC proteins". Biochimica et Biophysica Acta. 1461 (2): 237–62. doi:10.1016/s0005-2736(99)00161-3. PMID 10581359. 
  • Dean M, Rzhetsky A, Allikmets R (July 2001). "The human ATP-binding cassette (ABC) transporter superfamily". Genome Research. 11 (7): 1156–66. doi:10.1101/gr.184901. PMID 11435397. 
  • Hogue DL, Liu L, Ling V (January 1999). "Identification and characterization of a mammalian mitochondrial ATP-binding cassette membrane protein". Journal of Molecular Biology. 285 (1): 379–89. doi:10.1006/jmbi.1998.2259. PMID 9878413. 
  • Zhang F, Hogue DL, Liu L, Fisher CL, Hui D, Childs S, Ling V (July 2000). "M-ABC2, a new human mitochondrial ATP-binding cassette membrane protein". FEBS Letters. 478 (1-2): 89–94. doi:10.1016/S0014-5793(00)01823-8. PMID 10922475. 
  • Ye Z, Connor JR (August 2000). "cDNA cloning by amplification of circularized first strand cDNAs reveals non-IRE-regulated iron-responsive mRNAs". Biochemical and Biophysical Research Communications. 275 (1): 223–7. doi:10.1006/bbrc.2000.3282. PMID 10944468. 
  • Stanchi F, Bertocco E, Toppo S, Dioguardi R, Simionati B, Cannata N, Zimbello R, Lanfranchi G, Valle G (January 2001). "Characterization of 16 novel human genes showing high similarity to yeast sequences". Yeast. 18 (1): 69–80. doi:10.1002/1097-0061(200101)18:1<69::AID-YEA647>3.0.CO;2-H. PMID 11124703. 
  • Tsuda H, Ito YM, Ohashi Y, Wong KK, Hashiguchi Y, Welch WR, Berkowitz RS, Birrer MJ, Mok SC (October 2005). "Identification of overexpression and amplification of ABCF2 in clear cell ovarian adenocarcinomas by cDNA microarray analyses". Clinical Cancer Research. 11 (19 Pt 1): 6880–8. doi:10.1158/1078-0432.CCR-05-0751. PMID 16203778. 
  • Nishimura S, Tsuda H, Ito K, Jobo T, Yaegashi N, Inoue T, Sudo T, Berkowitz RS, Mok SC (January 2007). "Differential expression of ABCF2 protein among different histologic types of epithelial ovarian cancer and in clear cell adenocarcinomas of different organs". Human Pathology. 38 (1): 134–9. doi:10.1016/j.humpath.2006.06.026. PMID 16996567. 

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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