2-oxopent-4-enoate hydratase
| 2-oxopent-4-enoate hydratase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 4.2.1.80 | ||||||||
| CAS number | 64427-80-1 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / EGO | ||||||||
| |||||||||
In enzymology, a 2-oxopent-4-enoate hydratase (EC 4.2.1.80) is an enzyme that catalyzes the chemical reaction
- 4-hydroxy-2-oxopentanoate 2-oxopent-4-enoate + H2O
Hence, this enzyme has one substrate, 4-hydroxy-2-oxopentanoate, and two products, 2-oxopent-4-enoate and H2O.
This enzyme belongs to the family of lyases, specifically the hydro-lyases, which cleave carbon-oxygen bonds. The systematic name of this enzyme class is 4-hydroxy-2-oxopentanoate hydro-lyase (2-oxopent-4-enoate-forming). Other names in common use include 2-keto-4-pentenoate hydratase, OEH, 2-keto-4-pentenoate (vinylpyruvate)hydratase, and 4-hydroxy-2-oxopentanoate hydro-lyase. This enzyme participates in 9 metabolic pathways: phenylalanine metabolism, benzoate degradation via hydroxylation, biphenyl degradation, toluene and xylene degradation, 1,4-dichlorobenzene degradation, fluorene degradation, carbazole degradation, ethylbenzene degradation, and styrene degradation.
References
- Kunz DA, Ribbons DW, Chapman PJ (1981). "Metabolism of allylglycine and cis-crotylglycine by Pseudomonas putida (arvilla) mt-2 harboring a TOL plasmid". J. Bacteriol. 148 (1): 72–82. PMC 216168
. PMID 7287632.