Table of medication secernated in kidney

This is a table of medications that are secernated (that is, secreted) in the kidney.

Acid medication are, because of pH partition, secreted to a higher extent when urine is basic. In the same way, basic medications are secreted to a higher extent when urine is acidic.

Medication Location Acid or base [1] anion or cation[2] Percentage excreted[3]
para-aminohippurate proximal tubule[4] Acid anion
furosemide proximal tubule[4] Acid anion 100-75
glucuronic acid-conjugates proximal tubule[4] Acid
glycine conjugates proximal tubule[4] Acid
indometacin proximal tubule[4] Acid anion
methotrexate proximal tubule[4] Acid 100-75
penicillin proximal tubule[4] Acid anion 75-50
(benzylpenicillin)
probenecid proximal tubule[4] Acid anion
sulphate conjugates proximal tubule[4] Acid
thiazide diuretics proximal tubule[4] Acid
uric acid proximal tubule[4] Acid
amiloride proximal tubule[4] Base cation
dopamine proximal tubule[4] Base
histamine proximal tubule[4] Base
mepacrine proximal tubule[4] Base
morphine proximal tubule[4] Base cation
pethidine proximal tubule[4] Base
quaternary ammonium compounds proximal tubule[4] Base
quinine proximal tubule[4] Base cation
5 hydroxytryptamine proximal tubule[4] Base
triamterene proximal tubule[4] Base
gentamicin 100-75
atenolol 100-75
digoxin 100-75
cimetidine cation 75-50
tetracycline 75-50
(oxytetracycline)
neostigmine 75-50
propantheline ~50
tubocurarine ~50
acetazolamide proximal tubule[5] anion
chlorothiazide proximal tubule[5] anion
saccharin proximal tubule[5] anion
salicylate proximal tubule[5] anion
atropine proximal tubule[5] cation
NMN proximal tubule[5] cation
paraquat proximal tubule[5] cation
procainamide proximal tubule[5] cation
tetraethylammonium proximal tubule[5] cation
chlorpromazine proximal tubule[5] cation

References

  1. Unless else specified in table boxes, then ref is Rang, H. P. (2003). Pharmacology. Edinburgh: Churchill Livingstone. ISBN 0-443-07145-4. Page 112
  2. Unless else specified in table boxes, then ref is Walter F., PhD. Boron. Medical Physiology: A Cellular And Molecular Approach. Elsevier/Saunders. ISBN 1-4160-2328-3. Page 802
  3. Unless else specified in table boxes, then ref is Rang, H. P. (2003). Pharmacology. Edinburgh: Churchill Livingstone. ISBN 0-443-07145-4. Page 113
  4. 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 Rang, H. P. (2003). Pharmacology. Edinburgh: Churchill Livingstone. ISBN 0-443-07145-4. Page 112
  5. 1 2 3 4 5 6 7 8 9 10 Walter F., PhD. Boron. Medical Physiology: A Cellular And Molecular Approach. Elsevier/Saunders. ISBN 1-4160-2328-3. Page 802
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