TRNA-dihydrouridine16/17 synthase (NAD(P)+)
| TRNA-dihydrouridine16/17 synthase (NAD(P)+) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 1.3.1.88 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
TRNA-dihydrouridine16/17 synthase (NAD(P)+) (EC 1.3.1.88, Dus1p, tRNA-dihydrouridine synthase 1) is an enzyme with systematic name tRNA-5,6-dihydrouracil16/17:NAD(P)+ oxidoreductase.[1][2] This enzyme catalyses the following chemical reaction
- (1) 5,6-dihydrouracil16 in tRNA + NAD(P)+ uracil16 in tRNA + NAD(P)H + H+
- (2) 5,6-dihydrouracil17 in tRNA + NAD(P)+ uracil17 in tRNA + NAD(P)H + H+
This enzyme specifically modifies uracil16 and uracil17 in tRNA.
References
- ↑ Xing, F.; Hiley, S.L.; Hughes, T.R.; Phizicky, E.M. (2004). "The specificities of four yeast dihydrouridine synthases for cytoplasmic tRNAs". J. Biol. Chem. 279 (17): 17850–17860. doi:10.1074/jbc.M401221200. PMID 14970222.
- ↑ Xing, F.; Martzen, M.R.; Phizicky, E.M. (2002). "A conserved family of Saccharomyces cerevisiae synthases effects dihydrouridine modification of tRNA". RNA. 8: 370–381. doi:10.1017/S1355838202029825. PMC 1370258
. PMID 12003496.
External links
- TRNA-dihydrouridine16/17 synthase (NAD(P) ) at the US National Library of Medicine Medical Subject Headings (MeSH)
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