Maleate isomerase
| maleate isomerase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 5.2.1.1 | ||||||||
| CAS number | 9023-74-9 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / EGO | ||||||||
| |||||||||
In enzymology, a maleate isomerase (EC 5.2.1.1) is an enzyme that catalyzes the chemical reaction
- maleate fumarate
Hence, this enzyme has one substrate, maleate, and one product, fumarate.
This enzyme belongs to the family of isomerases, specifically cis-trans isomerases. The systematic name of this enzyme class is maleate cis-trans-isomerase. This enzyme participates in butanoate metabolism and nicotinate and nicotinamide metabolism.
References
- Behrmann EJ, Stanier RY (1957). "The bacterial oxidation of nicotinic acid". J. Biol. Chem. 228 (2): 923–45. PMID 13475371.
- Scher W, Jakoby WB (1969). "Maleate isomerase". J. Biol. Chem. 244 (7): 1878–82. PMID 5780844.
- Hatakeyama K, Asai Y, Uchida Y, Kobayashi M, Terasawa M, Yukawa H (1997). "Gene cloning and characterization of maleate cis-trans isomerase from Alcaligenes faecalis". Biochem. Biophys. Res. Commun. 239 (1): 74–9. doi:10.1006/bbrc.1997.7430. PMID 9345272.
- Hatakeyama K, Goto M, Uchida Y, Kobayashi M, Terasawa M, Yukawa H (2000). "Molecular analysis of maleate cis-trans isomerase from thermophilic bacteria". Biochem. Biophys. Res. Commun. 64 (3): 569–76. doi:10.1271/bbb.64.569. PMID 10803955.
- Fisch F, Fleites CM, Delenne M, Baudendistel N, Hauer B, Turkenburg JP, Hart S, Bruce NC, Grogan G (2010). "A covalent succinylcysteine-like intermediate in the enzyme-catalyzed transformation of maleate to fumarate by maleate isomerase". J. Am. Chem. Soc. 132 (33): 11455–7. doi:10.1021/ja1053576. PMID 20677745.
This article is issued from Wikipedia - version of the 5/25/2016. The text is available under the Creative Commons Attribution/Share Alike but additional terms may apply for the media files.