Ceramide glucosyltransferase
| Ceramide glucosyltransferase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 2.4.1.80 | ||||||||
| CAS number | 37237-44-8 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
Ceramide glucosyltransferase (or glucosylceramide synthase) is a glucosyltransferase enzyme involved in the production of glucocerebroside.[1]
It is classified under EC 2.4.1.80.
It is inhibited by miglustat and eliglustat, both drugs developed for the treatment of Gaucher disease.
See also
- Glucocerebroside (also called glucosylceramide)
References
- ↑ S Ichikawa; H Sakiyama; G Suzuki; K I Hidari; Y Hirabayashi (May 14, 1996). "Expression cloning of a cDNA for human ceramide glucosyltransferase that catalyzes the first glycosylation step of glycosphingolipid synthesis". PNAS. 93: 4638–4643. doi:10.1073/pnas.93.10.4638. PMC 39331
. PMID 8643456.
External links
- Ceramide glucosyltransferase at the US National Library of Medicine Medical Subject Headings (MeSH)
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